Carbapenem antibiotics in hospitalised paediatric patients. Adherence to a therapeutic protocol

Elena Montesinos-Sanchis, Fernando A. Moraga-Llop, Pere Soler-Palacín, María Oliveras-Arenas, M. Nieves Larrosa Escartín, Xavier Martínez Gómez, Concepción Figueras-Nadal

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© 2012 Elsevier España, S.L.U. and Sociedad Española de Enfermedades Infecciosas y Microbiología Clínica. All rights reserved. Objective: To describe the use of carbapenems in children hospitalised outside intensive care and oncohaematology units, and assess adherence to a therapeutic protocol. Patients and methods: A retrospective observational study was conducted on the use of carbapenems between January 2009 and December 2010. The study included children with a community-acquired infectious disease or a health care-associated infectious disease, and who were admitted to paediatric areas of the Vall d'Hebron University Hospital (Barcelona, Spain), other than intensive care, neonatology and onco-haematology units. Clinical data were collected and antibiotic consumption data were provided by the Pharmacy Department. Results: A total of 51 episodes fulfilled the inclusion criteria. Carbapenem as initial empirical treatment was indicated in 31.4%, and applied as rescue therapy in the remainder. The instructions of the protocol were adhered to in 70.6% of the empirical and 87.5% of the targeted prescriptions (77.6% overall). Abetter match was found for empirical carbapenem in patients with a previous admission or underlying condition. Factors such as diagnosis, age or antibiotic use prior to admission did not affect the empirical indication of carbapenem. Conclusions: The establishment of a treatment protocol with carbapenem indications in our centre since 2007 has yielded significantly better results on the appropriateness of the prescription than those obtained in other studies.
Original languageEnglish
Pages (from-to)647-653
JournalEnfermedades Infecciosas y Microbiologia Clinica
Issue number10
Publication statusPublished - 1 Jan 2014


  • Antimicrobial use
  • Carbapenems
  • Care-associated infection
  • Community-acquired infection and health
  • Paediatrics


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