Cannabis use and striatal D2 receptor density in untreated first-episode psychosis: An in vivo SPECT study

Gemma Safont, Iluminada Corripio, María J. Escartí, Maria J. Portella, Víctor Pérez, Marc Ferrer, Valle Camacho, Rosa B. Sauras, Anna Alonso, Eva M. Grasa, Belén Arranz, Luis San, Rosa Dueñas, Ignasi Carrió, Enric Álvarez

Research output: Contribution to journalArticleResearchpeer-review

13 Citations (Scopus)

Abstract

The biological basis of the association between cannabis-induced dopamine dysregulation and psychosis remains poorly understood. This (123)I-IBZM SPECT study assessed striatal dopamine D2 receptor (D2R) binding in 37 untreated first-episode psychosis (FEP) subjects, and 18 healthy controls. The aim was to examine if there were differences between FEP subjects with (n = 14) and without (n = 23) cannabis use in uptake ratios in the D2R. Striatal/Frontal cortex (S/F) uptake ratios were obtained. Healthy controls showed the lowest D2R binding ratios. No differences were found in S/F ratios between users and non-users, suggesting similar dopaminergic mechanisms underlying psychotic symptoms in both groups. © 2011 Elsevier B.V.
Original languageEnglish
Pages (from-to)169-171
JournalSchizophrenia Research
Volume129
Issue number2-3
DOIs
Publication statusPublished - 1 Jul 2011

Keywords

  • (123)I-IBZM SPECT
  • Cannabis
  • Dopamine D2 receptors
  • Psychosis

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