Cannabis use and striatal D2 receptor density in untreated first-episode psychosis: An in vivo SPECT study

Gemma Safont; Iluminada Corripio; María J. Escartí; Maria J. Portella; Víctor Pérez; Marc Ferrer; Valle Camacho; Rosa B. Sauras; Anna Alonso; Eva M. Grasa; Belén Arranz; Luis San; Rosa Dueñas; Ignasi Carrió; Enric Álvarez

doi:10.1016/j.schres.2011.03.012

Cannabis use and striatal D2 receptor density in untreated first-episode psychosis: An in vivo SPECT study

Gemma Safont, Iluminada Corripio, María J. Escartí, Maria J. Portella, Víctor Pérez, Marc Ferrer, Valle Camacho, Rosa B. Sauras, Anna Alonso, Eva M. Grasa, Belén Arranz, Luis San, Rosa Dueñas, Ignasi Carrió, Enric Álvarez

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13 Citations (Scopus)

Abstract

The biological basis of the association between cannabis-induced dopamine dysregulation and psychosis remains poorly understood. This (123)I-IBZM SPECT study assessed striatal dopamine D2 receptor (D2R) binding in 37 untreated first-episode psychosis (FEP) subjects, and 18 healthy controls. The aim was to examine if there were differences between FEP subjects with (n = 14) and without (n = 23) cannabis use in uptake ratios in the D2R. Striatal/Frontal cortex (S/F) uptake ratios were obtained. Healthy controls showed the lowest D2R binding ratios. No differences were found in S/F ratios between users and non-users, suggesting similar dopaminergic mechanisms underlying psychotic symptoms in both groups. © 2011 Elsevier B.V.

Original language	English
Pages (from-to)	169-171
Journal	Schizophrenia Research
Volume	129
Issue number	2-3
DOIs	https://doi.org/10.1016/j.schres.2011.03.012
Publication status	Published - 1 Jul 2011

Keywords

(123)I-IBZM SPECT
Cannabis
Dopamine D2 receptors
Psychosis

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10.1016/j.schres.2011.03.012

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Safont, G., Corripio, I., Escartí, M. J., Portella, M. J., Pérez, V., Ferrer, M., Camacho, V., Sauras, R. B., Alonso, A., Grasa, E. M., Arranz, B., San, L., Dueñas, R., Carrió, I., & Álvarez, E. (2011). Cannabis use and striatal D2 receptor density in untreated first-episode psychosis: An in vivo SPECT study. Schizophrenia Research, 129(2-3), 169-171. https://doi.org/10.1016/j.schres.2011.03.012

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title = "Cannabis use and striatal D2 receptor density in untreated first-episode psychosis: An in vivo SPECT study",

abstract = "The biological basis of the association between cannabis-induced dopamine dysregulation and psychosis remains poorly understood. This (123)I-IBZM SPECT study assessed striatal dopamine D2 receptor (D2R) binding in 37 untreated first-episode psychosis (FEP) subjects, and 18 healthy controls. The aim was to examine if there were differences between FEP subjects with (n = 14) and without (n = 23) cannabis use in uptake ratios in the D2R. Striatal/Frontal cortex (S/F) uptake ratios were obtained. Healthy controls showed the lowest D2R binding ratios. No differences were found in S/F ratios between users and non-users, suggesting similar dopaminergic mechanisms underlying psychotic symptoms in both groups. {\textcopyright} 2011 Elsevier B.V.",

keywords = "(123)I-IBZM SPECT, Cannabis, Dopamine D2 receptors, Psychosis",

author = "Gemma Safont and Iluminada Corripio and Escart{\'i}, {Mar{\'i}a J.} and Portella, {Maria J.} and V{\'i}ctor P{\'e}rez and Marc Ferrer and Valle Camacho and Sauras, {Rosa B.} and Anna Alonso and Grasa, {Eva M.} and Bel{\'e}n Arranz and Luis San and Rosa Due{\~n}as and Ignasi Carri{\'o} and Enric {\'A}lvarez",

year = "2011",

month = jul,

day = "1",

doi = "10.1016/j.schres.2011.03.012",

language = "English",

volume = "129",

pages = "169--171",

journal = "Schizophrenia Research",

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Safont, G, Corripio, I, Escartí, MJ, Portella, MJ, Pérez, V, Ferrer, M, Camacho, V, Sauras, RB, Alonso, A, Grasa, EM, Arranz, B, San, L, Dueñas, R, Carrió, I & Álvarez, E 2011, 'Cannabis use and striatal D2 receptor density in untreated first-episode psychosis: An in vivo SPECT study', Schizophrenia Research, vol. 129, no. 2-3, pp. 169-171. https://doi.org/10.1016/j.schres.2011.03.012

TY - JOUR

T1 - Cannabis use and striatal D2 receptor density in untreated first-episode psychosis: An in vivo SPECT study

AU - Safont, Gemma

AU - Corripio, Iluminada

AU - Escartí, María J.

AU - Portella, Maria J.

AU - Pérez, Víctor

AU - Ferrer, Marc

AU - Camacho, Valle

AU - Sauras, Rosa B.

AU - Alonso, Anna

AU - Grasa, Eva M.

AU - Arranz, Belén

AU - San, Luis

AU - Dueñas, Rosa

AU - Carrió, Ignasi

AU - Álvarez, Enric

PY - 2011/7/1

Y1 - 2011/7/1

N2 - The biological basis of the association between cannabis-induced dopamine dysregulation and psychosis remains poorly understood. This (123)I-IBZM SPECT study assessed striatal dopamine D2 receptor (D2R) binding in 37 untreated first-episode psychosis (FEP) subjects, and 18 healthy controls. The aim was to examine if there were differences between FEP subjects with (n = 14) and without (n = 23) cannabis use in uptake ratios in the D2R. Striatal/Frontal cortex (S/F) uptake ratios were obtained. Healthy controls showed the lowest D2R binding ratios. No differences were found in S/F ratios between users and non-users, suggesting similar dopaminergic mechanisms underlying psychotic symptoms in both groups. © 2011 Elsevier B.V.

AB - The biological basis of the association between cannabis-induced dopamine dysregulation and psychosis remains poorly understood. This (123)I-IBZM SPECT study assessed striatal dopamine D2 receptor (D2R) binding in 37 untreated first-episode psychosis (FEP) subjects, and 18 healthy controls. The aim was to examine if there were differences between FEP subjects with (n = 14) and without (n = 23) cannabis use in uptake ratios in the D2R. Striatal/Frontal cortex (S/F) uptake ratios were obtained. Healthy controls showed the lowest D2R binding ratios. No differences were found in S/F ratios between users and non-users, suggesting similar dopaminergic mechanisms underlying psychotic symptoms in both groups. © 2011 Elsevier B.V.

KW - (123)I-IBZM SPECT

KW - Cannabis

KW - Dopamine D2 receptors

KW - Psychosis

U2 - 10.1016/j.schres.2011.03.012

DO - 10.1016/j.schres.2011.03.012

M3 - Article

SN - 0920-9964

VL - 129

SP - 169

EP - 171

JO - Schizophrenia Research

JF - Schizophrenia Research

IS - 2-3

ER -

Cannabis use and striatal D2 receptor density in untreated first-episode psychosis: An in vivo SPECT study

Abstract

Keywords

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