Canine normal corneal epithelium bears a large population of CD45-positive cells

Andrea R.R. Carvalho, Carolina Naranjo, Marta Leiva Repiso, M. Dolores Fondevila Palau, Antoni Iborra, Paz Martinez, Maria Teresa Peña Gimenez

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4 Citations (Scopus)


This investigation sought to identify the presence of immune cells in normal canine corneal epithelium. A whole-mount immunofluorescence study of normal canine epithelium using monoclonal antibodies against CD45, CD11c, CD1c and MHC class II was performed. CD45-positive cells were located in all epithelial layers throughout the cornea, occurring in greater numbers (51.98 ± 4.1/mm2) at the periphery and decreasing towards the central region (11.8 ± 3.1/mm2). CD11c-positive cells were also observed, but were fewer in number. The findings show that the normal canine cornea carries a significant number of cells of immune origin; these cells seem to be of an inactive phenotype as they do not express MHC class II. Further studies are needed to determine whether these cells can express co-stimulatory molecules and act as antigen presenting cells if stimulated. © 2007 Elsevier Ltd. All rights reserved.
Original languageEnglish
Pages (from-to)437-442
JournalVeterinary Journal
Issue number3
Publication statusPublished - 1 Mar 2009


  • CD45
  • Cornea
  • Dog
  • Epithelium
  • Leucocyte

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