TY - JOUR
T1 - Canine intracranial meningiomas
T2 - Immunohistochemical evaluation of tissue factor, fibrin/fibrinogen and D-dimers
AU - Font, Cristina
AU - Fuente Hernandez, Cristian De La
AU - Pumarola Batlle, Marti
AU - Blasco Ortega, Ester
AU - Fernandez Flores, Francisco
AU - Viu Mella, Judit
AU - Añor Torres, Sonia
N1 - Publisher Copyright:
© 2015 Elsevier Ltd.
Copyright:
Copyright 2015 Elsevier B.V., All rights reserved.
PY - 2015/12/1
Y1 - 2015/12/1
N2 - The haemostatic system influences angiogenesis, cell growth and metastasis in solid tumours. The aim of this study was to investigate tissue factor (TF) expression, fibrin/fibrinogen and D-dimer deposition, as well as the occurrence of intravascular thrombosis (IVT) in canine intracranial meningiomas using immunohistochemistry. All but three (26/29) meningiomas expressed TF. TF immunolabelling was significantly higher in high-grade (grades II and III) than in low-grade (grade I) meningiomas. Fibrin/fibrinogen and D-dimer deposits were detected in all meningiomas and staining scores were statistically different between different meningioma grades. IVT was detected in 19/29 specimens, but no statistical differences were observed between different malignancy grades. In conclusion, the haemostatic system may be involved in meningioma pathobiology and may be a potential therapeutic target for canine meningiomas, as also suggested for human meningiomas.
AB - The haemostatic system influences angiogenesis, cell growth and metastasis in solid tumours. The aim of this study was to investigate tissue factor (TF) expression, fibrin/fibrinogen and D-dimer deposition, as well as the occurrence of intravascular thrombosis (IVT) in canine intracranial meningiomas using immunohistochemistry. All but three (26/29) meningiomas expressed TF. TF immunolabelling was significantly higher in high-grade (grades II and III) than in low-grade (grade I) meningiomas. Fibrin/fibrinogen and D-dimer deposits were detected in all meningiomas and staining scores were statistically different between different meningioma grades. IVT was detected in 19/29 specimens, but no statistical differences were observed between different malignancy grades. In conclusion, the haemostatic system may be involved in meningioma pathobiology and may be a potential therapeutic target for canine meningiomas, as also suggested for human meningiomas.
KW - Brain
KW - Coagulation
KW - Dog
KW - Fibrinolysis
KW - Immunohistochemistry
KW - Neoplasia
KW - Tissue factor
UR - http://www.scopus.com/inward/record.url?scp=84949205456&partnerID=8YFLogxK
U2 - 10.1016/j.tvjl.2015.07.008
DO - 10.1016/j.tvjl.2015.07.008
M3 - Article
C2 - 26526524
SN - 1090-0233
VL - 206
SP - 426
EP - 428
JO - Veterinary Journal
JF - Veterinary Journal
IS - 3
ER -