Candidemia in neonatal intensive care units: Barcelona, Spain

Dolors Rodriguez, Benito Almirante, Benjamin J. Park, Manuel Cuenca-Estrella, Ana M. Planes, Ferran Sanchez, Amadeu Gene, Mariona Xercavins, Dionisia Fontanals, Juan L. Rodriguez-Tudela, David W. Warnock, Albert Pahissa

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75 Citations (Scopus)


Background: Candida spp. are increasingly important hospitalacquired pathogens in neonatal intensive care units (NICU) and cause considerable mortality in preterm infants. Most studies have been limited to a single institution. The aim of this study was to determine the epidemiology of candidemia in all Barcelona NICUs. Methods: We conducted prospective population-based surveillance for candidemia in Barcelona, Spain, during 2002-2003. This report focuses on the results from 5 participating hospitals with NICUs. Results: We detected 24 cases, resulting in an annual incidence of 32.6 cases per 100,000 live births and 1.1 cases per 100 NICU discharges. Median gestational age was 27.5 weeks (range, 24-40.5), and there were 21 cases among very low birth weight infants. Among the 20 (83%) cases evaluated for the presence of end organ infection, endophthalmitis occurred in 2 cases, and endocarditis, meningitis and peritonitis occurred in 1 case each. Candida parapsilosis was the most frequent species isolated (67%). All isolates were fluconazole-susceptible. Crude mortality was 21%. Conclusions: The preponderance of C. parapsilosis candidemias observed in Barcelona NICUs is similar to reports from the literature. Morbidity and mortality associated with neonatal candidemia remain high. Copyright © 2006 by Lippincott Williams & Wilkins.
Original languageEnglish
Pages (from-to)224-229
JournalPediatric Infectious Disease Journal
Issue number3
Publication statusPublished - 1 Mar 2006


  • Azole resistance
  • Candidemia
  • Epidemiology
  • Neonatal intensive care unit
  • Risk factors for candidemia


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