Can sister chromatid intercrossings be considered as prelesions?

Carme Fuster, Rosa Mirò, Cristina Templado, Leonardo Barrios, Josep Egozcue

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Abstract

In a study of the expression of folate-sensitive fragile sites in five normal individuals using RPMI medium containing methotrexate (MTX), we observed a high frequency of "sister chromatid intercrossings" (SCI) that is, the intersection of sister chromatids. The location of SCIs corresponded to fragile sites in 54.2% of the cases. Of the SCIs observed in each individual, 43%-53% were located at the same bands as their expressed fragile sites. Furthermore when RPMI+MTX medium was used instead of F-10 medium, the incidence of SCIs increased tenfold. We suggest that SCIs could indicate the existence of a pre-lesion. © 1988 Springer-Verlag.
Original languageEnglish
Pages (from-to)179-180
JournalHuman Genetics
Volume79
DOIs
Publication statusPublished - 1 Jun 1988

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    Fuster, C., Mirò, R., Templado, C., Barrios, L., & Egozcue, J. (1988). Can sister chromatid intercrossings be considered as prelesions? Human Genetics, 79, 179-180. https://doi.org/10.1007/BF00280561