The World Health organization (WHO) has stated that the three leading causes of burden of disease In 2030 are projected to include HIV/AIDS, unipolar depression and schaemic heart disease. Aims To estimate health-related quality of life (HRQoL) and qualityadjusted life-year (QALY) losses associated with mental disorders and chronic physical conditions in primary healthcare using data from the diagnosis and treatment of mental disorders In primary care (DASMAP) study, an epidemiological survey carried out with primary care patients in Catalonia (Spain). Method A cross-sectional survey of a representative sample of 3815 primary care patients. A preference-based measure of health was derived from the 12-ltem Short Form Health Survey (SF-12): the Short Form-6D (SF-6D) multi-attribute healthstatus classification. Each profile generated by this questionnaire has a utility (or weight) assigned, we used non-parametric quantile regressions to model the association between both mental disorders and chronic physical condition and SF-6D scores. Results Conditions associated with SF-6D were: mood disorders, ß=-0.20 (95% Cl -0.18 to -0.21); pain, ß=-0.08 (95%Cl -0.06 to -0.09) and anxiety, ß=-0.04 (95% Cl -0.03 to -0.06). The top three causes of QALY losses annually per 100000 participants were pain (5064), mood disorders (2634) and anxiety (805). Conclusions Estimation of QALY losses showed that mood disorders ranked second behind pain-related chronic medical conditions.