Broadband homodecoupled time-shared 1H-13C and 1H-15N HSQC experiments

Pau Nolis, Kumar Motiram-Corral, Míriam Pérez-Trujillo, Teodor Parella

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Abstract

© 2018 Elsevier Inc. The concepts of pure-shift NMR and time-shared NMR are merged in a single experiment. A 13C/15N time-shared version of the real-time BIRD-based broadband homodecoupled HSQC experiment is described. This time-efficient approach affords simultaneously 1H-13C and 1H-15N pure-shift HSQC spectra in a single acquisition, while achieving substantial gains in both sensitivity and spectral resolution. We also present a related 13C/15N-F2-coupled homodecoupled version of the CLIP-HSQC experiment for the simultaneous measurement of 1JCH and 1JNH from the simplified doublets observed along the direct dimension. Finally, a novel J-resolved HSQC experiment has been designed for the simple and automated determination of both 1JCH/1JNH from a 2D J-resolved spectrum.
Original languageEnglish
Pages (from-to)23-30
JournalJournal of Magnetic Resonance
Volume298
DOIs
Publication statusPublished - 1 Jan 2019

Keywords

  • HSQC
  • J-resolved HSQC
  • NMR
  • Proton-carbon coupling constants
  • Proton-nitrogen coupling constants
  • Pure-shift HSQC
  • Time-shared NMR

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