Brief Report: HIV Infection Is Associated with Worse Bone Material Properties, Independently of Bone Mineral Density: HIV Infection Is Associated with Worse Bone Material Properties, Independently of Bone Mineral Density

Robert Güerri-Fernández; Daniel Molina; Judit Villar-García; Daniel Prieto-Alhambra; Leonardo Mellibovsky; Xavier Nogués; Alicia González-Mena; Ana Guelar; Marta Trenchs-Rodríguez; Sabina Herrera-Fernández; Juan Pablo Horcajada; Adolfo Díez-Pérez; Hernando Knobel

doi:10.1097/QAI.0000000000000965

Brief Report: HIV Infection Is Associated with Worse Bone Material Properties, Independently of Bone Mineral Density: HIV Infection Is Associated with Worse Bone Material Properties, Independently of Bone Mineral Density

Robert Güerri-Fernández^*, Daniel Molina, Judit Villar-García, Daniel Prieto-Alhambra, Leonardo Mellibovsky, Xavier Nogués, Alicia González-Mena, Ana Guelar, Marta Trenchs-Rodríguez, Sabina Herrera-Fernández, Juan Pablo Horcajada, Adolfo Díez-Pérez, Hernando Knobel

^*Corresponding author for this work

Department of Medicine

Research output: Contribution to journal › Article › Research › peer-review

31 Citations (Scopus)

Abstract

Low bone mineral density (BMD) in HIV-infected individuals has been documented in an increasing number of studies. However, it is not clear whether it is the infection itself or the treatment that causes bone impairment. Microindentation measures bone material strength (Bone Material Strength index) directly. We recruited 85 patients, 50 infected with HIV and 35 controls. Median Bone Material Strength index was 84.5 (interquartile range 83-87) in HIV-infected patients and 90 (88.5-93) in controls (P < 0.001). No significant differences in BMD between cases and controls at any of the sites examined (total hip, femoral neck, and lumbar spine). HIV infection is associated with bone damage, independently of BMD.

Original language	English
Pages (from-to)	314-318
Number of pages	5
Journal	Journal of acquired immune deficiency syndromes (1999)
Volume	72
Issue number	3
DOIs	https://doi.org/10.1097/QAI.0000000000000965
Publication status	Published - 1 Jul 2016

Keywords

BMD
bone material properties
HIV
microindentation

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Güerri-Fernández, R., Molina, D., Villar-García, J., Prieto-Alhambra, D., Mellibovsky, L., Nogués, X., González-Mena, A., Guelar, A., Trenchs-Rodríguez, M., Herrera-Fernández, S., Horcajada, J. P., Díez-Pérez, A., & Knobel, H. (2016). Brief Report: HIV Infection Is Associated with Worse Bone Material Properties, Independently of Bone Mineral Density: HIV Infection Is Associated with Worse Bone Material Properties, Independently of Bone Mineral Density. Journal of acquired immune deficiency syndromes (1999), 72(3), 314-318. https://doi.org/10.1097/QAI.0000000000000965

Güerri-Fernández, Robert ; Molina, Daniel ; Villar-García, Judit et al. / Brief Report: HIV Infection Is Associated with Worse Bone Material Properties, Independently of Bone Mineral Density : HIV Infection Is Associated with Worse Bone Material Properties, Independently of Bone Mineral Density. In: Journal of acquired immune deficiency syndromes (1999). 2016 ; Vol. 72, No. 3. pp. 314-318.

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title = "Brief Report: HIV Infection Is Associated with Worse Bone Material Properties, Independently of Bone Mineral Density: HIV Infection Is Associated with Worse Bone Material Properties, Independently of Bone Mineral Density",

abstract = "Low bone mineral density (BMD) in HIV-infected individuals has been documented in an increasing number of studies. However, it is not clear whether it is the infection itself or the treatment that causes bone impairment. Microindentation measures bone material strength (Bone Material Strength index) directly. We recruited 85 patients, 50 infected with HIV and 35 controls. Median Bone Material Strength index was 84.5 (interquartile range 83-87) in HIV-infected patients and 90 (88.5-93) in controls (P < 0.001). No significant differences in BMD between cases and controls at any of the sites examined (total hip, femoral neck, and lumbar spine). HIV infection is associated with bone damage, independently of BMD.",

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author = "Robert G{\"u}erri-Fern{\'a}ndez and Daniel Molina and Judit Villar-Garc{\'i}a and Daniel Prieto-Alhambra and Leonardo Mellibovsky and Xavier Nogu{\'e}s and Alicia Gonz{\'a}lez-Mena and Ana Guelar and Marta Trenchs-Rodr{\'i}guez and Sabina Herrera-Fern{\'a}ndez and Horcajada, {Juan Pablo} and Adolfo D{\'i}ez-P{\'e}rez and Hernando Knobel",

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Güerri-Fernández, R, Molina, D, Villar-García, J, Prieto-Alhambra, D, Mellibovsky, L, Nogués, X, González-Mena, A, Guelar, A, Trenchs-Rodríguez, M, Herrera-Fernández, S, Horcajada, JP, Díez-Pérez, A & Knobel, H 2016, 'Brief Report: HIV Infection Is Associated with Worse Bone Material Properties, Independently of Bone Mineral Density: HIV Infection Is Associated with Worse Bone Material Properties, Independently of Bone Mineral Density', Journal of acquired immune deficiency syndromes (1999), vol. 72, no. 3, pp. 314-318. https://doi.org/10.1097/QAI.0000000000000965

Brief Report: HIV Infection Is Associated with Worse Bone Material Properties, Independently of Bone Mineral Density: HIV Infection Is Associated with Worse Bone Material Properties, Independently of Bone Mineral Density. / Güerri-Fernández, Robert; Molina, Daniel; Villar-García, Judit et al.
In: Journal of acquired immune deficiency syndromes (1999), Vol. 72, No. 3, 01.07.2016, p. 314-318.

Research output: Contribution to journal › Article › Research › peer-review

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T2 - HIV Infection Is Associated with Worse Bone Material Properties, Independently of Bone Mineral Density

AU - Güerri-Fernández, Robert

AU - Molina, Daniel

AU - Villar-García, Judit

AU - Prieto-Alhambra, Daniel

AU - Mellibovsky, Leonardo

AU - Nogués, Xavier

AU - González-Mena, Alicia

AU - Guelar, Ana

AU - Trenchs-Rodríguez, Marta

AU - Herrera-Fernández, Sabina

AU - Horcajada, Juan Pablo

AU - Díez-Pérez, Adolfo

AU - Knobel, Hernando

PY - 2016/7/1

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N2 - Low bone mineral density (BMD) in HIV-infected individuals has been documented in an increasing number of studies. However, it is not clear whether it is the infection itself or the treatment that causes bone impairment. Microindentation measures bone material strength (Bone Material Strength index) directly. We recruited 85 patients, 50 infected with HIV and 35 controls. Median Bone Material Strength index was 84.5 (interquartile range 83-87) in HIV-infected patients and 90 (88.5-93) in controls (P < 0.001). No significant differences in BMD between cases and controls at any of the sites examined (total hip, femoral neck, and lumbar spine). HIV infection is associated with bone damage, independently of BMD.

AB - Low bone mineral density (BMD) in HIV-infected individuals has been documented in an increasing number of studies. However, it is not clear whether it is the infection itself or the treatment that causes bone impairment. Microindentation measures bone material strength (Bone Material Strength index) directly. We recruited 85 patients, 50 infected with HIV and 35 controls. Median Bone Material Strength index was 84.5 (interquartile range 83-87) in HIV-infected patients and 90 (88.5-93) in controls (P < 0.001). No significant differences in BMD between cases and controls at any of the sites examined (total hip, femoral neck, and lumbar spine). HIV infection is associated with bone damage, independently of BMD.

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SN - 1525-4135

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JO - Journal of acquired immune deficiency syndromes (1999)

JF - Journal of acquired immune deficiency syndromes (1999)

IS - 3

ER -

Güerri-Fernández R, Molina D, Villar-García J, Prieto-Alhambra D, Mellibovsky L, Nogués X et al. Brief Report: HIV Infection Is Associated with Worse Bone Material Properties, Independently of Bone Mineral Density: HIV Infection Is Associated with Worse Bone Material Properties, Independently of Bone Mineral Density. Journal of acquired immune deficiency syndromes (1999). 2016 Jul 1;72(3):314-318. doi: 10.1097/QAI.0000000000000965

Brief Report: HIV Infection Is Associated with Worse Bone Material Properties, Independently of Bone Mineral Density: HIV Infection Is Associated with Worse Bone Material Properties, Independently of Bone Mineral Density

Abstract

Keywords

UN SDGs

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