Breakable Hybrid Organosilica Nanocapsules for Protein Delivery

Eko Adi Prasetyanto, Alessandro Bertucci, Dedy Septiadi, Roberto Corradini, Pablo Castro-Hartmann, Luisa De Cola

    Research output: Contribution to journalArticleResearchpeer-review

    104 Citations (Scopus)


    © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. The direct delivery of specific proteins to live cells promises a tremendous impact for biological and medical applications, from therapeutics to genetic engineering. However, the process mostly involves tedious techniques and often requires extensive alteration of the protein itself. Herein we report a straightforward approach to encapsulate native proteins by using breakable organosilica matrices that disintegrate upon exposure to a chemical stimulus. The biomolecule-containing capsules were tested for the intracellular delivery of highly cytotoxic proteins into C6 glioma cells. We demonstrate that the shell is broken, the release of the active proteins occurs, and therefore our hybrid architecture is a promising strategy to deliver fragile biomacromolecules into living organisms.
    Original languageEnglish
    Pages (from-to)3323-3327
    JournalAngewandte Chemie - International Edition
    Issue number10
    Publication statusPublished - 1 Mar 2016


    • encapsulation
    • hybrid materials
    • nanostructures
    • organosilica
    • protein delivery


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