Brain tumor classification based on long echo proton MRS signals

L. Lukas, A. Devos, J. A.K. Suykens, L. Vanhamme, F. A. Howe, C. Majós, A. Moreno-Torres, M. Van Der Graaf, A. R. Tate, C. Arús, S. Van Huffel

Research output: Contribution to journalArticleResearchpeer-review

156 Citations (Scopus)


There has been a growing research interest in brain tumor classification based on proton magnetic resonance spectroscopy (1H MRS) signals. Four research centers within the EU funded INTERPRET project have acquired a significant number of long echo 1H MRS signals for brain tumor classification. In this paper, we present an objective comparison of several classification techniques applied to the discrimination of four types of brain tumors: meningiomas, glioblastomas, astrocytomas grade II and metastases. Linear and non-linear classifiers are compared: linear discriminant analysis (LDA), support vector machines (SVM) and least squares SVM (LS-SVM) with a linear kernel as linear techniques and LS-SVM with a radial basis function (RBF) kernel as a non-linear technique. Kernel-based methods can perform well in processing high dimensional data. This motivates the inclusion of SVM and LS-SVM in this study. The analysis includes optimal input variable selection, (hyper-) parameter estimation, followed by performance evaluation. The classification performance is evaluated over 200 stratified random samplings of the dataset into training and test sets. Receiver operating characteristic (ROC) curve analysis measures the performance of binary classification, while for multiclass classification, we consider the accuracy as performance measure. Based on the complete magnitude spectra, automated binary classifiers are able to reach an area under the ROC curve (AUC) of more than 0.9 except for the hard case glioblastomas versus metastases. Although, based on the available long echo 1H MRS data, we did not find any statistically significant difference between the performances of LDA and the kernel-based methods, the latter have the strength that no dimensionality reduction is required to obtain such a high performance. © 2004 Elsevier B.V. All rights reserved.
Original languageEnglish
Pages (from-to)73-89
JournalArtificial Intelligence in Medicine
Issue number1
Publication statusPublished - 1 May 2004


  • Brain tumors
  • Classification
  • Least squares support vector machine (LS-SVM)
  • Linear discriminant analysis (LDA)
  • Magnetic resonance spectroscopy (MRS)
  • Support vector machine (SVM)


Dive into the research topics of 'Brain tumor classification based on long echo proton MRS signals'. Together they form a unique fingerprint.

Cite this