Brain atrophy 15 years after CIS: Baseline and follow-up clinico-radiological correlations

Angela Vidal-Jordana, Jaume Sastre-Garriga, Deborah Pareto, Carmen Tur, Georgina Arrambide, Susana Otero-Romero, Elena Huerga, Raquel Mitjana, Cristina Auger, Mar Tintoré, Alex Rovira, Xavier Montalban

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Abstract

© 2017, © The Author(s), 2017. Background: Brain atrophy in multiple sclerosis (MS) patients is present since the very early stages of the disease and it has been related to long-term disability. Objective: To estimate brain volume (BV) at 15 years after a clinically isolated syndrome (CIS) and to evaluate its relationship with disease outcomes. Methods: From a prospective cohort including patients presenting with a CIS, 54 patients with a brain magnetic resonance imaging (MRI) performed 15 years after CIS were included. Brain parenchymal fraction (BPF), grey matter fraction (GMF) and white matter fraction (WMF) at 15-year follow-up were obtained. Regression analyses were conducted to predict BV loss and reaching an Expanded Disability Status Scale (EDSS) of 3.0 in that 15-year period. Results: In multivariable analyses, lower values of BPF and WMF were significantly associated with being male, presenting 3–4 Barkhof criteria at baseline, presenting a second relapse, and with a decision to start treatment. In the multivariable logistic regression analysis, only lower GMF was associated with a greater risk of reaching EDSS 3.0 (odds ratio (OR) = 0.24, p = 0.028). Conclusion: Lower BPF and WMF 15 years after CIS are associated with previous markers of inflammatory disease. Lower GMF 15 years after a CIS is associated with an increased risk of reaching an EDSS of 3.0.
Original languageEnglish
Pages (from-to)721-727
JournalMultiple Sclerosis Journal
Volume24
Issue number6
DOIs
Publication statusPublished - 1 May 2018

Keywords

  • Multiple sclerosis
  • atrophy
  • clinically isolated syndrome
  • grey matter

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    Vidal-Jordana, A., Sastre-Garriga, J., Pareto, D., Tur, C., Arrambide, G., Otero-Romero, S., Huerga, E., Mitjana, R., Auger, C., Tintoré, M., Rovira, A., & Montalban, X. (2018). Brain atrophy 15 years after CIS: Baseline and follow-up clinico-radiological correlations. Multiple Sclerosis Journal, 24(6), 721-727. https://doi.org/10.1177/1352458517707070