Brain atrophy 15 years after CIS: Baseline and follow-up clinico-radiological correlations

Angela Vidal-Jordana, Jaume Sastre-Garriga, Deborah Pareto, Carmen Tur, Georgina Arrambide, Susana Otero-Romero, Elena Huerga, Raquel Mitjana, Cristina Auger, Mar Tintoré, Alex Rovira, Xavier Montalban

Research output: Contribution to journalArticleResearchpeer-review

8 Citations (Scopus)


© 2017, © The Author(s), 2017. Background: Brain atrophy in multiple sclerosis (MS) patients is present since the very early stages of the disease and it has been related to long-term disability. Objective: To estimate brain volume (BV) at 15 years after a clinically isolated syndrome (CIS) and to evaluate its relationship with disease outcomes. Methods: From a prospective cohort including patients presenting with a CIS, 54 patients with a brain magnetic resonance imaging (MRI) performed 15 years after CIS were included. Brain parenchymal fraction (BPF), grey matter fraction (GMF) and white matter fraction (WMF) at 15-year follow-up were obtained. Regression analyses were conducted to predict BV loss and reaching an Expanded Disability Status Scale (EDSS) of 3.0 in that 15-year period. Results: In multivariable analyses, lower values of BPF and WMF were significantly associated with being male, presenting 3–4 Barkhof criteria at baseline, presenting a second relapse, and with a decision to start treatment. In the multivariable logistic regression analysis, only lower GMF was associated with a greater risk of reaching EDSS 3.0 (odds ratio (OR) = 0.24, p = 0.028). Conclusion: Lower BPF and WMF 15 years after CIS are associated with previous markers of inflammatory disease. Lower GMF 15 years after a CIS is associated with an increased risk of reaching an EDSS of 3.0.
Original languageEnglish
Pages (from-to)721-727
JournalMultiple Sclerosis Journal
Issue number6
Publication statusPublished - 1 May 2018


  • Multiple sclerosis
  • atrophy
  • clinically isolated syndrome
  • grey matter


Dive into the research topics of 'Brain atrophy 15 years after CIS: Baseline and follow-up clinico-radiological correlations'. Together they form a unique fingerprint.

Cite this