Bottom-Up Instructive Quality Control in the Biofabrication of Smart Protein Materials

Fabián Rueda, María Virtudes Céspedes, Oscar Conchillo-Solé, Alejandro Sánchez-Chardi, Joaquin Seras-Franzoso, Rafael Cubarsi, Alberto Gallardo, Mireia Pesarrodona, Neus Ferrer-Miralles, Xavier Daura, Esther Vázquez, Elena García-Fruitõs, Ramõn Mangues, Ugutz Unzueta, Antonio Villaverde

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36 Citations (Scopus)

Abstract

© 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. The impact of cell factory quality control on material properties is a neglected but critical issue in the fabrication of protein biomaterials, which are unique in merging structure and function. The molecular chaperoning of protein conformational status is revealed here as a potent molecular instructor of the macroscopic properties of self-assembling, cell-targeted protein nanoparticles, including biodistribution upon in vivo administration.
Original languageEnglish
Pages (from-to)7816-7822
JournalAdvanced Materials
Volume27
DOIs
Publication statusPublished - 16 Dec 2015

Keywords

  • biodistribution
  • biofabrication
  • cell quality control
  • nanoparticles
  • protein materials

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  • Cite this

    Rueda, F., Céspedes, M. V., Conchillo-Solé, O., Sánchez-Chardi, A., Seras-Franzoso, J., Cubarsi, R., Gallardo, A., Pesarrodona, M., Ferrer-Miralles, N., Daura, X., Vázquez, E., García-Fruitõs, E., Mangues, R., Unzueta, U., & Villaverde, A. (2015). Bottom-Up Instructive Quality Control in the Biofabrication of Smart Protein Materials. Advanced Materials, 27, 7816-7822. https://doi.org/10.1002/adma.201503676