Bottom-Up Instructive Quality Control in the Biofabrication of Smart Protein Materials

Fabián Rueda, María Virtudes Céspedes, Oscar Conchillo-Solé, Alejandro Sánchez-Chardi, Joaquin Seras-Franzoso, Rafael Cubarsi, Alberto Gallardo, Mireia Pesarrodona, Neus Ferrer-Miralles, Xavier Daura, Esther Vázquez, Elena García-Fruitõs, Ramõn Mangues, Ugutz Unzueta, Antonio Villaverde

Research output: Contribution to journalArticleResearchpeer-review

58 Citations (Scopus)


© 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. The impact of cell factory quality control on material properties is a neglected but critical issue in the fabrication of protein biomaterials, which are unique in merging structure and function. The molecular chaperoning of protein conformational status is revealed here as a potent molecular instructor of the macroscopic properties of self-assembling, cell-targeted protein nanoparticles, including biodistribution upon in vivo administration.
Original languageEnglish
Pages (from-to)7816-7822
JournalAdvanced Materials
Publication statusPublished - 16 Dec 2015


  • biodistribution
  • biofabrication
  • cell quality control
  • nanoparticles
  • protein materials


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