Bottom-Up Instructive Quality Control in the Biofabrication of Smart Protein Materials

Fabián Rueda; María Virtudes Céspedes; Oscar Conchillo-Solé; Alejandro Sánchez-Chardi; Joaquin Seras-Franzoso; Rafael Cubarsi; Alberto Gallardo; Mireia Pesarrodona; Neus Ferrer-Miralles; Xavier Daura; Esther Vázquez; Elena García-Fruitõs; Ramõn Mangues; Ugutz Unzueta; Antonio Villaverde

doi:10.1002/adma.201503676

Bottom-Up Instructive Quality Control in the Biofabrication of Smart Protein Materials

Fabián Rueda, María Virtudes Céspedes, Oscar Conchillo-Solé, Alejandro Sánchez-Chardi, Joaquin Seras-Franzoso, Rafael Cubarsi, Alberto Gallardo, Mireia Pesarrodona, Neus Ferrer-Miralles, Xavier Daura, Esther Vázquez, Elena García-Fruitõs, Ramõn Mangues, Ugutz Unzueta, Antonio Villaverde

Research output: Contribution to journal › Article › Research › peer-review

59 Citations (Scopus)

Abstract

© 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. The impact of cell factory quality control on material properties is a neglected but critical issue in the fabrication of protein biomaterials, which are unique in merging structure and function. The molecular chaperoning of protein conformational status is revealed here as a potent molecular instructor of the macroscopic properties of self-assembling, cell-targeted protein nanoparticles, including biodistribution upon in vivo administration.

Original language	English
Pages (from-to)	7816-7822
Journal	Advanced Materials
Volume	27
DOIs	https://doi.org/10.1002/adma.201503676
Publication status	Published - 16 Dec 2015

Keywords

biodistribution
biofabrication
cell quality control
nanoparticles
protein materials

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10.1002/adma.201503676

https://ddd.uab.cat/record/174136

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Rueda, F., Céspedes, M. V., Conchillo-Solé, O., Sánchez-Chardi, A., Seras-Franzoso, J., Cubarsi, R., Gallardo, A., Pesarrodona, M., Ferrer-Miralles, N., Daura, X., Vázquez, E., García-Fruitõs, E., Mangues, R., Unzueta, U., & Villaverde, A. (2015). Bottom-Up Instructive Quality Control in the Biofabrication of Smart Protein Materials. Advanced Materials, 27, 7816-7822. https://doi.org/10.1002/adma.201503676

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Rueda, F, Céspedes, MV, Conchillo-Solé, O, Sánchez-Chardi, A, Seras-Franzoso, J, Cubarsi, R, Gallardo, A, Pesarrodona, M, Ferrer-Miralles, N , Daura, X , Vázquez, E , García-Fruitõs, E, Mangues, R, Unzueta, U & Villaverde, A 2015, 'Bottom-Up Instructive Quality Control in the Biofabrication of Smart Protein Materials', Advanced Materials, vol. 27, pp. 7816-7822. https://doi.org/10.1002/adma.201503676

TY - JOUR

T1 - Bottom-Up Instructive Quality Control in the Biofabrication of Smart Protein Materials

AU - Rueda, Fabián

AU - Céspedes, María Virtudes

AU - Conchillo-Solé, Oscar

AU - Sánchez-Chardi, Alejandro

AU - Seras-Franzoso, Joaquin

AU - Cubarsi, Rafael

AU - Gallardo, Alberto

AU - Pesarrodona, Mireia

AU - Ferrer-Miralles, Neus

AU - Daura, Xavier

AU - Vázquez, Esther

AU - García-Fruitõs, Elena

AU - Mangues, Ramõn

AU - Unzueta, Ugutz

AU - Villaverde, Antonio

PY - 2015/12/16

Y1 - 2015/12/16

N2 - © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. The impact of cell factory quality control on material properties is a neglected but critical issue in the fabrication of protein biomaterials, which are unique in merging structure and function. The molecular chaperoning of protein conformational status is revealed here as a potent molecular instructor of the macroscopic properties of self-assembling, cell-targeted protein nanoparticles, including biodistribution upon in vivo administration.

AB - © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. The impact of cell factory quality control on material properties is a neglected but critical issue in the fabrication of protein biomaterials, which are unique in merging structure and function. The molecular chaperoning of protein conformational status is revealed here as a potent molecular instructor of the macroscopic properties of self-assembling, cell-targeted protein nanoparticles, including biodistribution upon in vivo administration.

KW - biodistribution

KW - biofabrication

KW - cell quality control

KW - nanoparticles

KW - protein materials

U2 - 10.1002/adma.201503676

DO - 10.1002/adma.201503676

M3 - Article

SN - 0935-9648

VL - 27

SP - 7816

EP - 7822

JO - Advanced Materials

JF - Advanced Materials

ER -

Bottom-Up Instructive Quality Control in the Biofabrication of Smart Protein Materials

Abstract

Keywords

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