TY - JOUR
T1 - Bone mass loss after sleeve gastrectomy: A prospective comparative study with gastric bypass
AU - Nogués, Xavier
AU - Goday, Albert
AU - Peña, Maria Jesus
AU - Benaiges, David
AU - de Ramón, Marta
AU - Crous, Xenia
AU - Vial, Manuel
AU - Pera, Manuel
AU - Grande, Luis
AU - Díez-Pérez, Adolfo
AU - Ramón, Jose Manuel
PY - 2010/8/1
Y1 - 2010/8/1
N2 - Introduction: Bariatric surgery is the most effective option for the treatment of patients with a high risk of complications due to their obesity. However, it brings about a series of changes in calcium and vitamin D metabolism and an increase in resorption which lead to a loss of bone mass. Aim: The objective of this study is to compare sleeve gastrectomy (SG) and Roux-en-Y gastric bypass (RYGB) as regards loss of bone mass using bone densitometry and bone remodelling markers. Patients and methods: Fifteen women with morbid obesity were included, 8 by SG and 7 by RYGB, with a mean age of 47.8±9 and mean body mass index 43.3±3.4. Bone mass measurements were made on the lumbar spine, femur and distal radius, and the bone remodelling markers N-telopeptide (NTx) and bone alkaline phosphatase (BALP), as well as vitamin D levels before and 12 months after surgery. Results: A significant bone mass loss was observed was observed with SG and RYGB, in the lumbar spine and hip, whilst no differences were observed in the radial. The percentage bone mass loss was less in the column and femur after SG than with RYGB, although it did not reach statistical significance, 4.6%±4.4 (mean±SD) and 6.3%±5.4 (mean±SD), respectively. At 12 months the Ntx increased for both types of surgery, and the BAP was only increased for SG. Conclusion: SG causes less, although not significant, bone mass loss compared to RYGB. © 2010 AEC.
AB - Introduction: Bariatric surgery is the most effective option for the treatment of patients with a high risk of complications due to their obesity. However, it brings about a series of changes in calcium and vitamin D metabolism and an increase in resorption which lead to a loss of bone mass. Aim: The objective of this study is to compare sleeve gastrectomy (SG) and Roux-en-Y gastric bypass (RYGB) as regards loss of bone mass using bone densitometry and bone remodelling markers. Patients and methods: Fifteen women with morbid obesity were included, 8 by SG and 7 by RYGB, with a mean age of 47.8±9 and mean body mass index 43.3±3.4. Bone mass measurements were made on the lumbar spine, femur and distal radius, and the bone remodelling markers N-telopeptide (NTx) and bone alkaline phosphatase (BALP), as well as vitamin D levels before and 12 months after surgery. Results: A significant bone mass loss was observed was observed with SG and RYGB, in the lumbar spine and hip, whilst no differences were observed in the radial. The percentage bone mass loss was less in the column and femur after SG than with RYGB, although it did not reach statistical significance, 4.6%±4.4 (mean±SD) and 6.3%±5.4 (mean±SD), respectively. At 12 months the Ntx increased for both types of surgery, and the BAP was only increased for SG. Conclusion: SG causes less, although not significant, bone mass loss compared to RYGB. © 2010 AEC.
KW - Bariatric surgery
KW - Bone densitometry
KW - Bone remodelling markers
KW - Osteoporosis
U2 - 10.1016/j.ciresp.2010.04.008
DO - 10.1016/j.ciresp.2010.04.008
M3 - Article
VL - 88
SP - 103
EP - 109
IS - 2
ER -
