Bone marrow mesenchymal stromal cells and olfactory ensheathing cells transplantation after spinal cord injury - a morphological and functional comparison in rats

Abel Torres-Espín, Elena Redondo-Castro, Joaquim Hernández, Xavier Navarro

Research output: Contribution to journalArticleResearchpeer-review

35 Citations (Scopus)

Abstract

Cell therapy for spinal cord injury (SCI) is a promising strategy for clinical application. Both bone marrow mesenchymal stromal cells (MSCs; also known as bone marrow-derived 'mesenchymal stem cells') and olfactory ensheathing cells (OECs) have demonstrated beneficial effects following transplantation in animal models of SCI. However, due to the large number of affecting parameters that determine the therapy success and the lack of methodological consensus, the comparison of different works is difficult. Therefore, we compared the effects of MSC and OEC transplants at early or delayed time after a spinal cord contusion injury in the rat. Functional outcomes for locomotion, sensory perception and electrophysiological responses were assessed. Moreover, the grafted cells survival and the amount of cavity and spared tissue were studied. The findings indicate that grafted cells survived until 7 days post-injection, but markedly disappeared in the following 2 weeks. Despite the low survival of the cells, MSC and OEC grafts provided tissue protection after early and delayed transplantation. Nevertheless, only acute MSC grafts improved locomotion recovery in treadmill condition and electrophysiological outcomes with respect to the other injured groups. These results, together with previous works, indicate that the MSC seem a better option than OEC for treatment of contusion injuries. © 2014 Federation of European Neuroscience Societies and John Wiley & Sons Ltd.
Original languageEnglish
Pages (from-to)1704-1717
JournalEuropean Journal of Neuroscience
Volume39
DOIs
Publication statusPublished - 1 Jan 2014

Keywords

  • Cell therapy
  • Mesenchymal stromal cells
  • Olfactory ensheathing cells
  • Spinal cord injury
  • Transplantation

Fingerprint Dive into the research topics of 'Bone marrow mesenchymal stromal cells and olfactory ensheathing cells transplantation after spinal cord injury - a morphological and functional comparison in rats'. Together they form a unique fingerprint.

Cite this