TY - JOUR
T1 - Bone health evaluation one year after aromatase inhibitors completion
AU - Pineda-Moncusí, Marta
AU - Servitja, Sonia
AU - Casamayor, Guillem
AU - Cos, Maria Lourdes
AU - Rial, Abora
AU - Rodriguez-Morera, Jaime
AU - Tusquets, Ignasi
AU - Diez-Perez, Adolfo
AU - Garcia-Giralt, Natalia
AU - Nogués, Xavier
PY - 2018/12/1
Y1 - 2018/12/1
N2 - © 2018 Elsevier Inc. Introduction: Breast cancer patients treated with aromatase inhibitors (AIs) experience increased bone loss during their treatment. However, there is little information about bone mineral density (BMD) after completing AI-treatment. The present study aimed to assess BMD changes one year after AI-therapy completion. Methods: Data were collected from 864 postmenopausal women treated with AI during 5 years (5y-AI group), or during 2–3 years after taking tamoxifen therapy (pTAM-AI group). Participants with osteoporosis were treated with oral bisphosphonates (BP). BMD changes in lumbar spine (LS), femoral neck (FN) and total hip (TH) between baseline, end of treatment, and at one year post-treatment were assessed using repeated-measures ANOVA. Results: At the end of AI-treatment, 382 patients had available BMD values and 316 also had post-treatment BMD values. As expected, BMD levels were decreased at AI-completion in non-BP treated patients. After one year, LS BMD increased in both groups (5y-AI: +2.11% [95%CI: 1.55 to 2.68], p < 0.001; pTAM-AI: +1.00% [95%CI: 0.49 to 1.51], p < 0.001) compared with the end of AI-therapy, while values at FN and TH remained stable. On the other hand, BMD values of BP-treated patients were increased or maintained at the end of AI-treatment and also at post-treatment. Conclusions: At one year after AI-completion, FN and TH BMD remained reduced in non-BP treated women, while LS BMD was recovered in the 5y-AI group and partially recovered in the pTAM-AI group. BP treatment increased or maintained BMD values at the end of therapy and at one year post-treatment.
AB - © 2018 Elsevier Inc. Introduction: Breast cancer patients treated with aromatase inhibitors (AIs) experience increased bone loss during their treatment. However, there is little information about bone mineral density (BMD) after completing AI-treatment. The present study aimed to assess BMD changes one year after AI-therapy completion. Methods: Data were collected from 864 postmenopausal women treated with AI during 5 years (5y-AI group), or during 2–3 years after taking tamoxifen therapy (pTAM-AI group). Participants with osteoporosis were treated with oral bisphosphonates (BP). BMD changes in lumbar spine (LS), femoral neck (FN) and total hip (TH) between baseline, end of treatment, and at one year post-treatment were assessed using repeated-measures ANOVA. Results: At the end of AI-treatment, 382 patients had available BMD values and 316 also had post-treatment BMD values. As expected, BMD levels were decreased at AI-completion in non-BP treated patients. After one year, LS BMD increased in both groups (5y-AI: +2.11% [95%CI: 1.55 to 2.68], p < 0.001; pTAM-AI: +1.00% [95%CI: 0.49 to 1.51], p < 0.001) compared with the end of AI-therapy, while values at FN and TH remained stable. On the other hand, BMD values of BP-treated patients were increased or maintained at the end of AI-treatment and also at post-treatment. Conclusions: At one year after AI-completion, FN and TH BMD remained reduced in non-BP treated women, while LS BMD was recovered in the 5y-AI group and partially recovered in the pTAM-AI group. BP treatment increased or maintained BMD values at the end of therapy and at one year post-treatment.
KW - Aromatase inhibitors
KW - B-ABLE cohort
KW - Bisphosphonates
KW - Bone mineral density
KW - Breast cancer
U2 - 10.1016/j.bone.2018.09.010
DO - 10.1016/j.bone.2018.09.010
M3 - Article
C2 - 30223134
VL - 117
SP - 54
EP - 59
JO - Bone
JF - Bone
SN - 8756-3282
ER -