Body temperature and response to thrombolytic therapy in acute ischaemic stroke

M. Millán, L. Grau, M. Castellanos, M. Rodríguez-Yáñez, J. F. Arenillas, F. Nombela, N. Pérez De La Ossa, L. López-Manzanares, J. Serena, J. Castillo, A. Dávalos

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    23 Citations (Scopus)


    Objective: To determine the relationship between body temperature (BT), arterial recanalization, functional outcome, and hemorrhagic transformation (HT) of cerebral infarction in patients treated with i.v. tissue plasminogen activator (tPA). Methods: We studied 254 patients treated with tPA within 3 h from stroke onset. National Institute of Health Stroke Scale score, BT, and transcranial Doppler ultrasound (n = 99) on admission and at 24 h were recorded. Hypodensity volume and HT were evaluated on CT at 24-36 h. Poor outcome (Rankin Scale > 2) was evaluated at 3 months. Results: Arterial recanalization at 24 h was found in 70.7% of patients, HT in 24.8% (symptomatic in 4.7%) and poor outcome in 44.1%. Baseline BT was not associated with greater stroke severity at admission or at 24 h, HT or poor outcome. However, BT at 24 h correlated to stroke severity (P < 0.001) and hypodensity volume (P < 0.001) at 24 h, and was higher in patients who did not recanalize (P = 0.001), had symptomatic HT (P = 0.063) and poor outcome (P < 0.001). The adjusted odds ratio of poor outcome for patients with BT at 24 h ≥ 37°C was 2.56 (1.19-5.50, P = 0.016). Conclusion: Body temperature ≥37°C at 24 h, but not at baseline, is associated with a lack of recanalization, greater hypodensity volume and worse outcome in stroke patients treated with tPA. © 2008 The Author(s).
    Original languageEnglish
    Pages (from-to)1384-1389
    JournalEuropean Journal of Neurology
    Issue number12
    Publication statusPublished - 1 Jan 2008


    • Hyperthermia
    • Ischaemic stroke
    • Temperature
    • Thrombolysis


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