TY - GEN
T1 - Blunted Autonomic Reactivity to Mental Stress in Depression Quantified by Nonlinear Cardiorespiratory Coupling Indices
AU - Kontaxis, Spyridon
AU - Laguna, Pablo
AU - Garcia, Esther
AU - Miguel, Mar Posadas De
AU - Siddi, Sara
AU - Bernal, Maria Luisa
AU - Haro, Josep Maria
AU - Aguilo, Jordi
AU - De La Camara, Concepcion
AU - Bailon, Raquel
AU - Gil, Eduardo
N1 - Publisher Copyright:
© 2020 Creative Commons; the authors hold their copyright.
Copyright:
Copyright 2021 Elsevier B.V., All rights reserved.
PY - 2020/9/13
Y1 - 2020/9/13
N2 - In this study, differences in autonomic reactivity to mental stress between Major Depressive Disorder (MDD) patients and healthy control (HC) subjects are assessed by nonlinear cardiorespiratory coupling indices derived from the Real Wavelet Biphase. The degree and strength of Quadratic Phase Coupling (QPC) between interacting oscillations of Heart Rate Variability (HRV) and respiration are quantified before, during and after the execution of a cognitive task. Results show that the QPC strength and QPC degree between the respiration and the respiratory sinus arrhythmia component of HRV were lower in HC compared to MDD during stress, suggesting that the parasympathetic branch was less inhibited in MDD patients. During recovery, only in HC group, this degree of QPC increased, while the respiratory rate was reduced, compared to the basal stage. The degree of QPC between the respiration and components of HRV in the low frequency band ([0.04, 0.15] Hz) increased in HC during stress, compared to the basal stage, while remained unchanged in MDD patients. These results imply that depression is associated with blunted autonomic reactivity to mental stress.
AB - In this study, differences in autonomic reactivity to mental stress between Major Depressive Disorder (MDD) patients and healthy control (HC) subjects are assessed by nonlinear cardiorespiratory coupling indices derived from the Real Wavelet Biphase. The degree and strength of Quadratic Phase Coupling (QPC) between interacting oscillations of Heart Rate Variability (HRV) and respiration are quantified before, during and after the execution of a cognitive task. Results show that the QPC strength and QPC degree between the respiration and the respiratory sinus arrhythmia component of HRV were lower in HC compared to MDD during stress, suggesting that the parasympathetic branch was less inhibited in MDD patients. During recovery, only in HC group, this degree of QPC increased, while the respiratory rate was reduced, compared to the basal stage. The degree of QPC between the respiration and components of HRV in the low frequency band ([0.04, 0.15] Hz) increased in HC during stress, compared to the basal stage, while remained unchanged in MDD patients. These results imply that depression is associated with blunted autonomic reactivity to mental stress.
UR - http://www.scopus.com/inward/record.url?scp=85100940244&partnerID=8YFLogxK
U2 - 10.22489/CinC.2020.233
DO - 10.22489/CinC.2020.233
M3 - Other contribution
AN - SCOPUS:85100940244
T3 - Computing in Cardiology
PB - IEEE Computer Society
ER -