Blood PGC-1α concentration predicts myocardial salvage and ventricular remodeling after st-segment elevation acute myocardial infarction

Óscar Fabregat-Andrés, Francisco Ridocci-Soriano, Jordi Estornell-Erill, Miguel Corbí-Pascual, Alfonso Valle-Muñoz, Alberto Berenguer-Jofresa, José A. Barrabés, Manuel Mata, María Monsalve

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Abstract

© 2015 Sociedad Española de Cardiologia. Introduction and objectives Peroxisome proliferator-activated receptor gamma coactivator 1α (PGC-1α) is a metabolic regulator induced during ischemia that prevents cardiac remodeling in animal models. The activity of PGC-1α can be estimated in patients with ST-segment elevation acute myocardial infarction. The aim of the present study was to evaluate the value of PGC-1α in blood in predicting the extent of necrosis and ventricular remodeling after infarction. Methods In this prospective study of 31 patients with a first myocardial infarction in an anterior location and successful reperfusion, PGC-1α expression in peripheral blood on admission and at 72 hours was correlated with myocardial injury, ventricular volume, and systolic function at 6 months. Edema and myocardial necrosis were estimated using cardiac magnetic resonance imaging during the first week. At 6 months, infarct size and ventricular remodeling, defined as an increase > 10% of the left ventricular end-diastolic volume, was evaluated by follow-up magnetic resonance imaging. Myocardial salvage was defined as the difference between the edema and necrosis areas. Results Greater myocardial salvage was seen in patients with detectable PGC-1α levels at admission (mean [standard deviation (SD)], 18.3% [5.3%] vs 4.5% [3.9%]; P =.04). Induction of PGC-1α at 72 hours correlated with greater ventricular remodeling (change in left ventricular end-diastolic volume at 6 months, 29.7% [11.2%] vs 1.2% [5.8%]; P =.04). Conclusions Baseline PGC-1α expression and an attenuated systemic response after acute myocardial infarction are associated with greater myocardial salvage and predict less ventricular remodeling.
Original languageEnglish
Pages (from-to)408-416
JournalRevista Espanola de Cardiologia
Volume68
Issue number5
DOIs
Publication statusPublished - 1 Jan 2015

Keywords

  • infarction
  • Oxidative metabolism
  • Oxidative stress
  • PGC-1α
  • ST-segment elevation acute myocardial
  • Ventricular remodeling

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    Fabregat-Andrés, Ó., Ridocci-Soriano, F., Estornell-Erill, J., Corbí-Pascual, M., Valle-Muñoz, A., Berenguer-Jofresa, A., Barrabés, J. A., Mata, M., & Monsalve, M. (2015). Blood PGC-1α concentration predicts myocardial salvage and ventricular remodeling after st-segment elevation acute myocardial infarction. Revista Espanola de Cardiologia, 68(5), 408-416. https://doi.org/10.1016/j.recesp.2014.05.020