Blood concentrations of persistent organic pollutants and prediabetes and diabetes in the general population of Catalonia

Magda Gasull, José Pumarega, María Téllez-Plaza, Conxa Castell, Ricard Tresserras, Duk Hee Lee, Miquel Porta

Research output: Contribution to journalArticleResearchpeer-review

51 Citations (Scopus)

Abstract

The aim was to analyze the effects of body mass index (BMI), low-dose exposure, mixtures of persistent organic pollutants (POPs), and lipid adjustment on the relationship between POP concentrations and diabetes and prediabetes in the general adult population of Catalonia (Spain). Serum concentrations of POPs were measured by gas chromatography with electron-capture detection in 886 participants in a health interview survey. The highest concentrations of all POPs analyzed were found in subjects who had diabetes. Levels were also higher in individuals with prediabetes than in subjects without the disorder. In models adjusted by age, sex and BMI, the prevalence of diabetes and prediabetes increased in a dose-dependent manner across quartiles of PCBs 118, 138, 153, and 180, and HCB. When models were further adjusted for lipids, the associations were slightly lower and statistically significant, the ORs for the upper quartile ranging from 2.0 to 2.8 (all p-values for linear trend <0.05). Concentrations of p,p′-DDT, p,p′-DDE and β-HCH were not associated with diabetes or prediabetes. Increasing concentrations of PCBs and HCB were positively associated with diabetes and prediabetes. Only part of the association was due to age and BMI. Findings support the hypothesis that exposure to POPs may be a diabetogenic factor in both obese and nonobese individuals. © 2012 American Chemical Society.
Original languageEnglish
Pages (from-to)7799-7810
JournalEnvironmental Science and Technology
Volume46
Issue number14
DOIs
Publication statusPublished - 17 Jul 2012

Fingerprint

Dive into the research topics of 'Blood concentrations of persistent organic pollutants and prediabetes and diabetes in the general population of Catalonia'. Together they form a unique fingerprint.

Cite this