Blockade of opioid receptors with naltrexone inhibits thyrotropin increase after noise stress but does not prevent the decrease caused by immobilization

A. Armario, O. Marti, A. Gavalda, T. Jolin

    Research output: Contribution to journalArticleResearchpeer-review

    2 Citations (Scopus)

    Abstract

    The influence of naltrexone-induced opioid receptor blockade on the response of thyrotropin to two different acute Stressors was studied in adult male rats. Naltrexone slightly but significantly reduced basal thyrotropin levels and abolished the increase in serum thyrotropin caused by acute noise stress. In contrast, the opioid antagonist did not prevent the decrease in serum thyrotropin caused by another much more severe stressor such as immobilization. The present data offer the first evidence that endogenous opioids could play a stimulatory role in the control of thyrotropin secretion in a presumably physiological condition such as the response to a mild stressor. In addition, factors other than opioids could be involved in the inhibition of thyrotropin secretion under severe stress. © 1990.
    Original languageEnglish
    Pages (from-to)347-349
    JournalBrain Research Bulletin
    Volume25
    DOIs
    Publication statusPublished - 1 Jan 1990

    Keywords

    • Endogenous opioids
    • Immobilization stress
    • Naltrexone
    • Noise stress
    • Thyrotropin

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