Blinatumomab for treating acute lymphoblastic leukemia

Josep Maria Ribera, Susana Vives, Cristina Motlló, María José Jiménez-Lorenzo

Research output: Contribution to journalReview articleResearchpeer-review

Abstract

© 2015 Informa UK, Ltd. Introduction: Immunotherapy is a promising modality of treatment for neoplastic diseases. The CD19/CD3-bispecific T cell-engaging (BiTE®) monoclonal antibody blinatumomab can transiently engage any cytotoxic T cells to CD19+ target B cells inducing their serial lysis. Blinatumomab has shown promising activity in B-cell non-Hodgkin's lymphomas and, especially, in B-cell precursor acute lymphoblastic leukemia (ALL).Areas covered: This review focuses on the chemistry, pharmacological properties, clinical activity as well as the safety and tolerability of blinatumomab used in the treatment of relapsed/refractory (R/R) (including minimal residual disease-positive [MRD+]) ALL in adults and children.Expert opinion: Blinatumomab has demonstrated encouraging response rates in the setting of MRD+ and in R/R ALL in adults and children. Blinatumomab has a favorable safety profile, although reversible CNS events and cytokine release syndrome can occur. Encouraging reports on the activity of blinatumomab in the R/R B-cell precursor ALL led to its approval by the US FDA after an accelerated review process on 3 December 2014.
Original languageEnglish
Pages (from-to)477-485
JournalExpert Opinion on Orphan Drugs
Volume3
Issue number4
DOIs
Publication statusPublished - 1 Apr 2015

Keywords

  • Acute lymphoblastic leukemia
  • BiTE® monoclonal antibodies
  • Blinatumomab
  • Minimal residual disease-positive
  • Relapsed/refractory

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