Biotransformation of chloramphenicol by white-rot-fungi Trametes versicolor under cadmium stress

Zewen Tan, Diana Losantos, Yongtao Li, Montserrat Sarrà*

*Corresponding author for this work

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)
3 Downloads (Pure)


The recalcitrant chloramphenicol (CAP) combined with heavy metals cadmium (Cd) commonly co-existed in the environment, posing threat to environment health. The capacity of Trametes versicolor to remove/biodegrade CAP in air-pulse fluidized-bed reactor was evaluated, even under Cd stress. T. versicolor could remove 44 % CAP of 5 mg/L in 15 days, even 51 % CAP under 1 mg/L Cd stress. Sustained Cd stress inhibited CAP biodegradation and Cd removal in a 5-batches of a 5-days cycle sequential batch reactor. Nine transformation products and two novel pathways were proposed, with initial multi-step transformation reaction into CP2 and allylic alcohol, respectively. Furthermore, the main mechanism of Cd removal by T. versicolor was extracellular surface bioadsorption and intracellular accumulation. This study filled the gap of the mechanism of simultaneous CAP removal/biodegradation and Cd removal by white-rot fungi T. versicolor, which offer a theoretical basis for future application of biological removal of CAP containing wastewater.

Original languageEnglish
Article number128508
Number of pages8
JournalBioresource Technology
Publication statusPublished - Feb 2023


  • Biotransformation pathway
  • Cadmium stress
  • Chloramphenicol biotransformation
  • Fluidized-bed reactor
  • Trametes versicolor


Dive into the research topics of 'Biotransformation of chloramphenicol by white-rot-fungi Trametes versicolor under cadmium stress'. Together they form a unique fingerprint.

Cite this