Biomass Estimation in Plant Cell Cultures Using an Extended Kalman Filter

Joan Albiol, Jordi Robusté, Carles Casas, Manel Poch

Research output: Contribution to journalArticleResearchpeer-review

39 Citations (Scopus)


Use of carbohydrate concentration measurements linked to a digital filter was studied for biomass estimation in plant cell cultures. Due to the high complexity of the biological system, the strategy followed has been to work with a simple model and to rely on the filter to adapt the values of the model parameters to changes in the system behavior. Results obtained with this approach have shown the method to be efficient for biomass estimation, both in Erlenmeyer flasks and in bioreactors with changing operational conditions. Copyright © 1993 American Institute of Chemical Engineers (AIChE)
Original languageEnglish
Pages (from-to)174-178
JournalBiotechnology Progress
Issue number2
Publication statusPublished - 1 Jan 1993


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