TY - JOUR
T1 - Biomarkers for diagnosis and monitoring of celiac disease
AU - Vives-Pi, Marta
AU - Takasawa, Shin
AU - Pujol-Autonell, Irma
AU - Planas, Raquel
AU - Cabre, Eduard
AU - Ojanguren, Isabel
AU - Montraveta, Montserrat
AU - Santos, Agustin L.
AU - Ruiz-Ortiz, Estíbaliz
PY - 2013/4/1
Y1 - 2013/4/1
N2 - Celiac disease (CD) is an autoimmune disorder, which damages the small intestine and is caused by ingestion of gluten in genetically susceptible individuals. The only known effective treatment is a lifelong gluten-free diet. Genetic risk factors have been identified and nearly all patients are HLA-DQ2 and/or HLA-DQ8 positive. Specific autoantibodies, IgA antitissue transglutaminase-2, antiendomysium, and antideaminated forms of gliadin peptide antibodies, are widely used as diagnostic aids in celiac patients. However, the discovery of new biomarkers may help in the diagnosis and follow-up of the disease. Recently, the molecule REG Iα, involved in tissue regeneration, has been proposed as a new biomarker of CD. REG Iα expression is increased in the target tissue and in the sera of celiac patients during damage and inflammation, decreasing after gluten-free diet. In this article we review the main biomarkers for diagnosis and monitoring of CD, focusing on the immune response-related mechanisms. Copyright © 2013 by Lippincott Williams & Wilkins.
AB - Celiac disease (CD) is an autoimmune disorder, which damages the small intestine and is caused by ingestion of gluten in genetically susceptible individuals. The only known effective treatment is a lifelong gluten-free diet. Genetic risk factors have been identified and nearly all patients are HLA-DQ2 and/or HLA-DQ8 positive. Specific autoantibodies, IgA antitissue transglutaminase-2, antiendomysium, and antideaminated forms of gliadin peptide antibodies, are widely used as diagnostic aids in celiac patients. However, the discovery of new biomarkers may help in the diagnosis and follow-up of the disease. Recently, the molecule REG Iα, involved in tissue regeneration, has been proposed as a new biomarker of CD. REG Iα expression is increased in the target tissue and in the sera of celiac patients during damage and inflammation, decreasing after gluten-free diet. In this article we review the main biomarkers for diagnosis and monitoring of CD, focusing on the immune response-related mechanisms. Copyright © 2013 by Lippincott Williams & Wilkins.
KW - Autoimmunity
KW - Biomarkers
KW - Celiac disease
KW - Small intestine
U2 - 10.1097/MCG.0b013e31827874e3
DO - 10.1097/MCG.0b013e31827874e3
M3 - Review article
SN - 0192-0790
VL - 47
SP - 308
EP - 313
JO - Journal of Clinical Gastroenterology
JF - Journal of Clinical Gastroenterology
IS - 4
ER -
