Biomarkers for diagnosis and monitoring of celiac disease

Marta Vives-Pi, Shin Takasawa, Irma Pujol-Autonell, Raquel Planas, Eduard Cabre, Isabel Ojanguren, Montserrat Montraveta, Agustin L. Santos, Estíbaliz Ruiz-Ortiz

Research output: Contribution to journalReview articleResearchpeer-review

35 Citations (Scopus)


Celiac disease (CD) is an autoimmune disorder, which damages the small intestine and is caused by ingestion of gluten in genetically susceptible individuals. The only known effective treatment is a lifelong gluten-free diet. Genetic risk factors have been identified and nearly all patients are HLA-DQ2 and/or HLA-DQ8 positive. Specific autoantibodies, IgA antitissue transglutaminase-2, antiendomysium, and antideaminated forms of gliadin peptide antibodies, are widely used as diagnostic aids in celiac patients. However, the discovery of new biomarkers may help in the diagnosis and follow-up of the disease. Recently, the molecule REG Iα, involved in tissue regeneration, has been proposed as a new biomarker of CD. REG Iα expression is increased in the target tissue and in the sera of celiac patients during damage and inflammation, decreasing after gluten-free diet. In this article we review the main biomarkers for diagnosis and monitoring of CD, focusing on the immune response-related mechanisms. Copyright © 2013 by Lippincott Williams & Wilkins.
Original languageEnglish
Pages (from-to)308-313
JournalJournal of Clinical Gastroenterology
Issue number4
Publication statusPublished - 1 Apr 2013


  • Autoimmunity
  • Biomarkers
  • Celiac disease
  • Small intestine


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