Bioimpedance dispersion width as a parameter to monitor living tissues

Antoni Ivorra*, Meritxell Genescà, Anna Sola, Luis Palacios, Rosa Villa, Georgina Hotter, Jordi Aguiló

*Corresponding author for this work

Research output: Contribution to journalArticleResearchpeer-review

49 Citations (Scopus)


In the case of living tissues, the spectral width of the electrical bioimpedance dispersions (closely related with the α parameter in the Cole equation) evolves during the ischemic periods. This parameter is often ignored in favor of other bioimpedance parameters such as the central frequency or the resistivity at low frequencies. The object of this paper is to analyze the significance of this parameter through computer simulations (in the α and β dispersion regions) and to demonstrate its practical importance through experimental studies performed in rat kidneys during cold preservation. The simulations indicate that the dispersion width could be determined by the morphology of the extra-cellular spaces. The experimental studies show that it is a unique parameter able to detect certain conditions such as a warm ischemia period prior to cold preservation or the effect of a drug (Swinholide A) able to disrupt the cytoskeleton. The main conclusion is that, thanks to the α parameter in the Cole equation, the bioimpedance is not only useful to monitor the intra/extra-cellular volume imbalances or the inter-cellular junctions resistance but also to detect tissue structural alterations.

Original languageEnglish
Pages (from-to)S165-S173
JournalPhysiological Measurement
Issue number2
Publication statusPublished - Apr 2005


  • Bioimpedance
  • Cole
  • Cytoskeleton
  • Dispersion width
  • Monitoring
  • Morphology


Dive into the research topics of 'Bioimpedance dispersion width as a parameter to monitor living tissues'. Together they form a unique fingerprint.

Cite this