Biodegradation of the X-ray contrast agent iopromide and the fluoroquinolone antibiotic ofloxacin by the white rot fungus Trametes versicolor in hospital wastewaters and identification of degradation products

Meritxell Gros, Carles Cruz-Morato, Ernest Marco-Urrea, Philipp Longrée, Heinz Singer, Montserrat Sarrà, Juliane Hollender, Teresa Vicent, Sara Rodriguez-Mozaz, Damià Barceló

    Research output: Contribution to journalArticleResearchpeer-review

    65 Citations (Scopus)

    Abstract

    This paper describes the degradation of the X-ray contrast agent iopromide (IOP) and the antibiotic ofloxacin (OFLOX) by the white-rot-fungus Trametes versicolor. Batch studies in synthetic medium revealed that between 60 and 80% of IOP and OFLOX were removed when spiked at approximately 12mgL-1 and 10mgL-1, respectively. A significant number of transformation products (TPs) were identified for both pharmaceuticals, confirming their degradation. IOP TPs were attributed to two principal reactions: (i) sequential deiodination of the aromatic ring and (ii) N-dealkylation of the amide at the hydroxylated side chain of the molecule. On the other hand, OFLOX transformation products were attributed mainly to the oxidation, hydroxylation and cleavage of the piperazine ring.Experiments in 10L-bioreactor with fungal biomass fluidized by air pulses operated in batch achieved high percentage of degradation of IOP and OFLOX when load with sterile (87% IOP, 98.5% OFLOX) and unsterile (65.4% IOP, 99% OFLOX) hospital wastewater (HWW) at their real concentration (μgL-1 level). Some of the most relevant IOP and OFLOX TPs identified in synthetic medium were also detected in bioreactor samples. Acute toxicity tests indicated a reduction of the toxicity in the final culture broth from both experiments in synthetic medium and in batch bioreactor. © 2014 Elsevier Ltd.
    Original languageEnglish
    Pages (from-to)228-241
    JournalWater Research
    Volume60
    DOIs
    Publication statusPublished - 1 Sep 2014

    Keywords

    • Bioreactor
    • Hospital wastewater
    • Pharmaceutical compounds
    • White-rot fungi

    Fingerprint

    Dive into the research topics of 'Biodegradation of the X-ray contrast agent iopromide and the fluoroquinolone antibiotic ofloxacin by the white rot fungus Trametes versicolor in hospital wastewaters and identification of degradation products'. Together they form a unique fingerprint.

    Cite this