Biodegradable Peptide-Silica Nanodonuts

Laura Maggini, Leana Travaglini, Ingrid Cabrera, Pablo Castro-Hartmann, Luisa De Cola

    Research output: Contribution to journalArticleResearchpeer-review

    30 Citations (Scopus)


    © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. We report hybrid organosilica toroidal particles containing a short peptide sequence as the organic component of the hybrid systems. Once internalised in cancer cells, the presence of the peptide allows for interaction with peptidase enzymes, which attack the nanocarrier effectively triggering its structural breakdown. Moreover, these biodegradable nanovectors are characterised by high cellular uptake and exocytosis, showing great potential as biodegradable drug carriers. To demonstrate this feature, doxorubicin was employed and its delivery in HeLa cells investigated.
    Original languageEnglish
    Pages (from-to)3697-3703
    JournalChemistry - A European Journal
    Issue number11
    Publication statusPublished - 7 Mar 2016


    • biodegradability
    • breakable particles
    • drug delivery
    • hybrid organosilica particles
    • materials science


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