Biodegradable FeMnSi sputter-coated macroporous polypropylene membranes for the sustained release of drugs

Jordina Fornell, Jorge Soriano, Miguel Guerrero, Juan de Dios Sirvent, Marta Ferran-Marqués, Elena Ibáñez, Leonardo Barrios, Maria Dolors Baró, Santiago Suriñach, Carme Nogués, Jordi Sort, Eva Pellicer

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

Abstract

© 2017 by the authors. Licensee MDPI, Basel, Switzerland. Pure Fe and FeMnSi thin films were sputtered on macroporous polypropylene (PP) membranes with the aim to obtain biocompatible, biodegradable and, eventually, magnetically-steerable platforms. Room-temperature ferromagnetic response was observed in both Fe- and FeMnSi-coated membranes. Good cell viability was observed in both cases by means of cytotoxicity studies, though the FeMnSi-coated membranes showed higher biodegradability than the Fe-coated ones. Various strategies to functionalize the porous platforms with transferrin-Alexa Fluor 488 (Tf-AF488) molecules were tested to determine an optimal balance between the functionalization yield and the cargo release. The distribution of Tf-AF488 within the FeMnSi-coated PP membranes, as well as its release and uptake by cells, was studied by confocal laser scanning microscopy. A homogeneous distribution of the drug within the membrane skeleton and its sustained release was achieved after three consecutive impregnations followed by the addition of a layer made of gelatin and maltodextrin, which prevented exceedingly fast release. The here-prepared organic-inorganic macroporous membranes could find applications as fixed or magnetically-steerable drug delivery platforms.
Original languageEnglish
Article number155
Pages (from-to)1-12
JournalNanomaterials
Volume7
Issue number155
DOIs
Publication statusPublished - 1 Jul 2017

Keywords

  • Biodegradable material
  • Drug delivery
  • Hybrid material
  • Porous membrane

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