Bioactive lipids in inflammation after central nervous system injury

Rubèn López-Vales, Samuel David

Research output: Chapter in BookChapterResearchpeer-review

11 Citations (Scopus)

Abstract

© Springer Nature Switzerland AG 2019. Despite the progress made over the last decades to understand the mechanisms underlying tissue damage and neurological deficits after neurotrauma, there are currently no effective treatments in the clinic. It is well accepted that the inflammatory response in the CNS after injury exacerbates tissue loss and functional impairments. Unfortunately, the use of potent anti-inflammatory drugs, such as methylprednisolone, fails to promote therapeutic recovery and also gives rise to several undesirable side effects related to immunosuppression. The injury-induced inflammatory response is complex, and understanding the mechanisms that regulate this inflammation is therefore crucial in the quest to develop effective treatments. Bioactive lipids have emerged as potent molecules in controlling the initiation, coordination, and resolution of inflammation and in promoting tissue repair and recovery of homeostasis. These bioactive lipids are produced by cells involved in the inflammatory response, and their defective synthesis leads to persistent chronic inflammation, tissue damage, and fibrosis. The present chapter discusses recent evidence for the role of some of these bioactive lipids, in particular, eicosanoid and pro-resolving lipid mediators, in the regulation of inflammation after neurotrauma and highlights the therapeutic potential of some of these lipids in enhancing neurological outcomes after CNS injuries.
Original languageEnglish
Title of host publicationAdvances in Experimental Medicine and Biology
EditorsA Trostchansky, H Rubbo
Pages181-194
Number of pages14
Volume1127
DOIs
Publication statusPublished - 1 Jan 2019

Publication series

NameAdvances in Experimental Medicine and Biology
PublisherSPRINGER INTERNATIONAL PUBLISHING AG
Volume1127
ISSN (Print)0065-2598

Keywords

  • Eicosanoids
  • Inflammation
  • Neurotrauma
  • Resolution
  • Specialized pro-resolving mediators
  • EMERGING ROLES
  • BRAIN-INJURY
  • MICE DEFICIENT
  • DP1 RECEPTOR
  • PROSTAGLANDIN-D SYNTHASE
  • LEUKOTRIENE B-4
  • PRO-RESOLVING MEDIATORS
  • PGE(2) EP2 RECEPTOR
  • PHOSPHOLIPASE A(2) SUPERFAMILY
  • SPINAL-CORD-INJURY

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