Beta-adrenergic blocking effects and cardiodepressant activity of penbutolol and its two optical isomers in the guinea-pig left atrium

A. Badia, P. Bermejo, F. Jane

    Research output: Contribution to journalArticleResearchpeer-review

    Abstract

    The beta-adrenoceptor blocking potency and cardiodepressant activity of penbutolol and its two isomers have been evaluated in the guinea-pig left atrium in order to determine if the two properties are related. While (-)-penbutolol was ten times more potent than (+)-penbutolol and three times more potent than (±)-penbutolol as a beta-adrenoceptor antagonist, the three compounds showed a similar activity as cardiodepressant agents. These results seem to demonstrate that it is unlikely that this depressant action can be related to the antagonism of beta adrenoceptors.
    Original languageEnglish
    Pages (from-to)445-448
    JournalMethods and Findings in Experimental and Clinical Pharmacology
    Volume6
    Issue number8
    Publication statusPublished - 1 Dec 1984

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