Beneficial effect of donepezil on sensorimotor function after stroke

Marcelo L. Berthier, Jesús Pujol, Alexandre Gironell, Jaime Kulisevsky, Joan Deus, Julían Hinojosa, Carles Soriano-Mas

Research output: Contribution to journalArticleResearchpeer-review

25 Citations (Scopus)


Pharmacotherapy of poststroke sensorimotor deficits is currently used alone or combined with physiotherapy to promote recovery of mobility problems. This case study examined the effectiveness of donepezil hydrochloride (HCl) administered to a stroke patient with chronic, dense, left sensorimotor deficit. The patient received donepezil HCl (5 mg daily for 4 wk, followed by 10 mg daily for 12 wk) but no physiotherapy. Baseline and posttreatment evaluations were performed with the Fugl-Meyer scale and the Rivermead Mobility Index. One month after starting donepezil HCl (10 mg/day), sensorimotor function improved dramatically in the hemiplegic lower limb and shoulder. It was concluded that donepezil HCl may be an effective treatment for improving sensorimotor function in chronic stroke patients. Randomized controlled trials are required to support these preliminary findings.
Original languageEnglish
Pages (from-to)725-729
JournalAmerican Journal of Physical Medicine and Rehabilitation
Publication statusPublished - 1 Sep 2003


  • Bereitschaftspotentials
  • Donepezil Hydrochloride
  • Functional Magnetic Resonance Imaging
  • Sensorimotor Deficits
  • Stroke
  • Transcranial Magnetic Stimulation


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