Behavior of the 9-anthryl-tert-butylcarbinol as a chiral solvating agent. Study of diastereochemical association by intermolecular NOE and molecular dynamics calculations

M. De Moragas, E. Cervelló, A. Port, C. Jaime, A. Virgili, B. Ancian

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20 Citations (Scopus)

Abstract

The 9-anthryl-tert-butylcarbinol was tested as a chiral solvating agent (CSA) in the presence of racemic forms of mentil-p-toluenesulfinate, 9-(1- amino-2,2-dimethylpropyl)-9,19-dihydroanthracene, α-methoxyphenylacetic acid and 1-phenyl-1,2-ethanediol. Diastereomeric complexes were found to form between each enantiomer of these last two compounds. One of the enantiomers of 9-anthryltert-butylcarbinol was studied by means of intermolecular NOE and molecular dynamics calculations. Major thermodynamic and structural differences were found.
Original languageEnglish
Pages (from-to)8689-8695
JournalJournal of Organic Chemistry
Volume63
Issue number24
DOIs
Publication statusPublished - 27 Nov 1998

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