Bayes factor for testing the genetic background of quantitative threshold traits

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6 Citations (Scopus)

Abstract

The recent development of the Bayes factor methodology to test between nested competing models has allowed to evaluate the genetic component of continuous traits through a methodology based on the reparameterization of a variance component model in terms of intraclass correlation. In this study, we present a modification of that procedure to compare between threshold models that only differ in a bounded variable. An extra data-augmentation step is required to sample liability, an underlying continuous variable related with phenotypic records through an adequate number of thresholds. In this context, we describe a procedure to sample from a truncated multivariate normal distribution with non-null covariances between records, taking as starting point the Cholesky factorization and the inclusion of linear restrictions. The method was tested by computer simulations with satisfactory results. © 2006 Blackwell Verlag.
Original languageEnglish
Pages (from-to)301-306
JournalJournal of Animal Breeding and Genetics
Volume123
DOIs
Publication statusPublished - 1 Oct 2006

Keywords

  • Bayes factor
  • Cholesky
  • Data augmentation
  • Heritability
  • Threshold

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