TY - JOUR
T1 - Baseline circulating ghrelin does not predict weight regain neither maintenance of weight loss after gastric bypass at long term
AU - Pellitero, Silvia
AU - Pérez-Romero, Noelia
AU - Martínez, Eva
AU - Granada, María L.
AU - Moreno, Pau
AU - Balibrea, Jose M.
AU - Tarascó, Jordi
AU - Lucas, Anna
AU - Puig-Domingo, Manel
PY - 2015/1/1
Y1 - 2015/1/1
N2 - © 2015 Elsevier Inc. All rights reserved. Background Predictors of weight loss (WL) or weight regain (WR) after Roux-en-Y gastric bypass (RYGBP) are not established. The aim of this study was to analyze the usefulness of some baseline peptides (leptin, insulin, and ghrelin) as biomarkers of WL and WR in morbid obese patients after RYGBP at long term. Methods Seventy-six morbid obese (47 women, age 41.6 ± 9.6 years, body mass index [BMI] 52.1 ± 8 kg/m2) patients were evaluated at baseline and at 1, 2, and 6 years after surgery. Results Excess body weight loss after 6 years was of 63.9%. Age, BMI, and studied hormones at baseline or their changes over time did not predict long-term excess body weight loss. WR greater than 10% was observed in 36.8% of patients between 2 and 6 years of follow-up, but it was not correlated with BMI, age, or baseline peptide concentrations. Conclusion Measurement of ghrelin, insulin, and leptin before surgery is not useful as predictors of WL or WR at long term after RYGBP.
AB - © 2015 Elsevier Inc. All rights reserved. Background Predictors of weight loss (WL) or weight regain (WR) after Roux-en-Y gastric bypass (RYGBP) are not established. The aim of this study was to analyze the usefulness of some baseline peptides (leptin, insulin, and ghrelin) as biomarkers of WL and WR in morbid obese patients after RYGBP at long term. Methods Seventy-six morbid obese (47 women, age 41.6 ± 9.6 years, body mass index [BMI] 52.1 ± 8 kg/m2) patients were evaluated at baseline and at 1, 2, and 6 years after surgery. Results Excess body weight loss after 6 years was of 63.9%. Age, BMI, and studied hormones at baseline or their changes over time did not predict long-term excess body weight loss. WR greater than 10% was observed in 36.8% of patients between 2 and 6 years of follow-up, but it was not correlated with BMI, age, or baseline peptide concentrations. Conclusion Measurement of ghrelin, insulin, and leptin before surgery is not useful as predictors of WL or WR at long term after RYGBP.
KW - Gastric bypass
KW - Ghrelin
KW - Leptin
KW - Weight regain
U2 - 10.1016/j.amjsurg.2014.08.040
DO - 10.1016/j.amjsurg.2014.08.040
M3 - Article
SN - 0002-9610
VL - 210
SP - 340
EP - 344
JO - American Journal of Surgery
JF - American Journal of Surgery
IS - 2
ER -