Bariatric surgery in morbidly obese patients improves the atherogenic qualitative properties of the plasma lipoproteins

Josep Julve, Eva Pardina, Montserrat Pérez-Cuéllar, Roser Ferrer, Joana Rossell, Juan Antonio Baena-Fustegueras, José Manuel Fort, Albert Lecube, Francisco Blanco-Vaca, José Luis Sánchez-Quesada, Julia Peinado-Onsurbe

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20 Citations (Scopus)


Objective: The purpose of this study was to evaluate the effect of weight loss induced in morbidly obese subjects by Roux-en-Y gastric bypass bariatric surgery on the atherogenic features of their plasma lipoproteins. Methods: Twenty-one morbidly obese subjects undergoing bariatric surgery were followed up for up to 1 year after surgery. Plasma and lipoproteins were assayed for chemical composition and lipoprotein-associated phospholipase A2 (Lp-PLA2) activity. Lipoprotein size was assessed by non-denaturing polyacrylamide gradient gel electrophoresis, and oxidised LDL by ELISA. Liver samples were assayed for mRNA abundance of oxidative markers. Results: Lipid profile analysis revealed a reduction in the plasma concentrations of cholesterol and triglycerides, which were mainly associated with a significant reduction in the plasma concentration of circulating apoB-containing lipoproteins rather than with changes in their relative chemical composition. All patients displayed a pattern A phenotype of LDL subfractions and a relative increase in the antiatherogenic plasma HDL-2 subfraction (>2-fold; P<0.001). The switch towards predominantly larger HDL particles was due to an increase in their relative cholesteryl ester content. Excess weight loss also led to a significant decrease in the plasma concentration of oxidised LDL (~-25%; P<0.01) and in the total Lp-PLA2 activity. Interestingly, the decrease in plasma Lp-PLA2 was mainly attributed to a decrease in the apoB-containing lipoprotein-bound Lp-PLA2. Conclusion: Our data indicate that the weight loss induced by bariatric surgery ameliorates the atherogenicity of plasma lipoproteins by reducing the apoB-containing Lp-PLA2 activity and oxidised LDL, as well as increasing the HDL-2 subfraction. © 2014 Elsevier Ireland Ltd.
Original languageEnglish
Pages (from-to)200-205
Issue number1
Publication statusPublished - 1 Jan 2014


  • Bariatric surgery
  • HDL
  • Lipoprotein-associated phospholipase A2 (Lp-PLA2)
  • Obesity
  • Oxidised LDL
  • Weight loss


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