Autophagic pathways and parkinson disease

Miquel Vila, Marta Martinez-Vicente

Research output: Chapter in BookChapterResearchpeer-review

Abstract

© Springer Science+Business Media New York 2014. All rights reserved. Autophagy is responsible for the degradation and recycling of intracellular material including organelles, cytosolic proteins, and accumulated misfolded proteins. Increasing evidence implicates autophagy dysfunction in several neurodegenerative disorders including Parkinson's disease (PD). In this chapter, we analyze recent studies that provide new links between genes associated to PD and the autophagy process. Mutations in PD-associated proteins like a-synuclein, parkin, PINK1, LRRK2, DJ-1, UCH-L1, ATP12A3, and GBA have been recently directly or indirectly linked to alterations in the autophagic system, thereby contributing to the understanding of the role of this system in the pathogenesis of Parkinson's disease.
Original languageEnglish
Title of host publicationHandbook of Neurotoxicity
Pages727-751
Number of pages24
Volume2
DOIs
Publication statusPublished - 1 Jan 2014

Keywords

  • A-synuclein
  • ATP12A3
  • Autophagy
  • DJ-1
  • GBA
  • LRRK2
  • PINK1
  • Parkin
  • Parkinson's disease
  • UCH-L1

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