Automated Quality Control for Proton Magnetic Resonance Spectroscopy Data Using Convex Non-negative Matrix Factorization.

Victor Mocioiu, Sreenath P. Kyathanahally, Carles Arús, Alfredo Vellido, Margarida Julià-Sapé*

*Corresponding author for this work

Research output: Chapter in BookChapterResearchpeer-review

5 Citations (Scopus)

Abstract

Proton Magnetic Resonance Spectroscopy (1H MRS) has proven its diagnostic potential in a variety of conditions. However, MRS is not yet widely used in clinical routine because of the lack of experts on its diagnostic interpretation. Although data-based decision support systems exist to aid diagnosis, they often take for granted that the data is of good quality, which is not always the case in a real application context. Systems based on models built with bad quality data are likely to underperform in their decision support tasks. In this study, we propose a system to filter out such bad quality data. It is based on convex Non-Negative Matrix Factorization models, used as a dimensionality reduction procedure, and on the use of several classifiers to discriminate between good and bad quality data.

Original languageAmerican English
Title of host publicationBioinformatics and Biomedical Engineering. IWBBIO 2016. Lecture Notes in Computer Science()
Pages 719–727
Number of pages9
Volume9656
ISBN (Electronic)978-3-319-31744-1
DOIs
Publication statusPublished - Mar 2016

Publication series

NameLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Volume9656
ISSN (Print)0302-9743
ISSN (Electronic)1611-3349

Keywords

  • Brain tumors
  • Convex non-negative matrix factorization
  • Machine learning
  • Magnetic resonance spectroscopy
  • Pattern recognition
  • Quality control

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