Automated cytology readings of urine: A preliminary retrospective study

Ivonne Vázquez, Francesc Alameda, Sergi Mojal, Susana Calvo, Emilia Romero, Amparo Quiñonero, Inma Soler, Raquel Albero-González, Belén Lloveras, Lara Pijuan, Sergi Serrano

Research output: Contribution to journalArticleResearchpeer-review

Abstract

© 2014 SEAP y SEC. ThinPrep® Imager system reading method of liquid-based cytology is currently a very helpful tool for both the cytotechnologist and the pathologist. Some authors have shown the usefulness of liquid-based cytology ThinPrep® as a replacement of the citospin in urine cytology. However, there is very little information about its usefulness. Objective: To evaluate the utility of reading urine cytology using ThinPrep® Imager System. Material and methods: A retrospective study of 180 urine cytology smears was carried out. Processing was done according to ThinPrep® platform protocol, automated staining with stainer Leica® and manual reading of the slide and diagnosis, followed by automated reading of cytology using Imager®. Review by cytotechnologists. Results: The results were classified as positive, negative, atypia or polioma.Diagnostic coincidence was 83.9% (Kappa; 95%IC, 0.713 [0,619-0,807]). All positive cases were detected by the automated system. Of the 118 cases previously interpreted as negative, 97 (82%) were reinterpreted as such. None previously reported as negative were interpreted as positive in the study with Imager®.Sensitivity as well as negative predictive value of the Imager® for the detection of carcinoma in this series are 100%. The specificity is 98% and the positive predictive value is 91%.The cytotechnologist reviewed 75/180 slides (41.7%), mostly with atypia (89.6%) or negative (32,3%). Conclusions: The use of the Imager® as a pre-screening method could help in the interpretation of urine cytology and a useful tool for the cytotechnologist. The percentage of cases that do not require complete revision could increase with the experience of the cytotechnologist.
Original languageEnglish
Pages (from-to)199-203
JournalRevista Espanola de Patologia
Volume47
Issue number4
DOIs
Publication statusPublished - 1 Jan 2014

Keywords

  • Imager ®
  • ThinPrep ®
  • Urine cytology

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