Autoimmune/inflammatory syndrome induced by adjuvants (ASIA) demonstrates distinct autoimmune and autoinflammatory disease associations according to the adjuvant subtype: Insights from an analysis of 500 cases

Abdulla Watad; Nicola Luigi Bragazzi; Dennis McGonagle; Mohammed Adawi; Charlie Bridgewood; Giovanni Damiani; Jaume Alijotas-Reig; Enrique Esteve-Valverde; Mariana Quaresma; Howard Amital; Yehuda Shoenfeld

doi:10.1016/j.clim.2019.03.007

Autoimmune/inflammatory syndrome induced by adjuvants (ASIA) demonstrates distinct autoimmune and autoinflammatory disease associations according to the adjuvant subtype: Insights from an analysis of 500 cases

Abdulla Watad, Nicola Luigi Bragazzi, Dennis McGonagle, Mohammed Adawi, Charlie Bridgewood, Giovanni Damiani, Jaume Alijotas-Reig, Enrique Esteve-Valverde, Mariana Quaresma, Howard Amital, Yehuda Shoenfeld

Department of Medicine

Research output: Contribution to journal › Article › Research › peer-review

103 Citations (Scopus)

Abstract

BACKGROUND: We investigated the pattern of reported immune diseases in the international ASIA syndrome registry.

METHODS: Data from 500 subjects exposed to adjuvants from the ASIA syndrome international registry were analysed.

RESULTS: The patient mean age was 43 ± 17 years and 89% were female. Within the reported immune diseases, 69% were well-defined immune diseases (autoimmune, autoinflammation, and mixed pattern diseases). Among the well-defined immune diseases following the exposure to adjuvants, polygenic autoimmune diseases were significantly higher than autoinflammatory disorders (92.7% vs 5.8%, respectively, p < 0.001). Polygenic autoimmune diseases such as connective tissue diseases were significantly linked to the exposure to HBV vaccine (OR 3.15 [95%CI 1.08-9.23], p = 0.036). Polygenic autoinflammatory diseases were significantly associated with the exposure to influenza vaccination (OR 10.98 [95%CI 3.81-31.67], p < 0.0001).

CONCLUSIONS: Immune conditions following vaccination are rare, and among these, polygenic autoimmune diseases represent the vast majority of the well-defined immune diseases reported under the umbrella ASIA syndrome. However, vaccines benefit outweighs their autoimmune side effects.

Original language	English
Pages (from-to)	1-8
Number of pages	8
Journal	Clinical Immunology
Volume	203
DOIs	https://doi.org/10.1016/j.clim.2019.03.007
Publication status	Published - Jun 2019

Keywords

Adjuvants, Immunologic
Adolescent
Adult
Aged
Aged, 80 and over
Autoimmune Diseases/epidemiology
Child
Child, Preschool
Connective Tissue Diseases/epidemiology
Female
Giant Cell Arteritis/epidemiology
Hepatitis B Vaccines/immunology
Humans
Infant
Infant, Newborn
Inflammation/epidemiology
Influenza Vaccines/immunology
Israel/epidemiology
Male
Middle Aged
Syndrome
Vaccination/statistics & numerical data
Young Adult

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Watad, A., Bragazzi, N. L., McGonagle, D., Adawi, M., Bridgewood, C., Damiani, G., Alijotas-Reig, J., Esteve-Valverde, E., Quaresma, M., Amital, H., & Shoenfeld, Y. (2019). Autoimmune/inflammatory syndrome induced by adjuvants (ASIA) demonstrates distinct autoimmune and autoinflammatory disease associations according to the adjuvant subtype: Insights from an analysis of 500 cases. Clinical Immunology, 203, 1-8. https://doi.org/10.1016/j.clim.2019.03.007

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title = "Autoimmune/inflammatory syndrome induced by adjuvants (ASIA) demonstrates distinct autoimmune and autoinflammatory disease associations according to the adjuvant subtype: Insights from an analysis of 500 cases",

abstract = "BACKGROUND: We investigated the pattern of reported immune diseases in the international ASIA syndrome registry.METHODS: Data from 500 subjects exposed to adjuvants from the ASIA syndrome international registry were analysed.RESULTS: The patient mean age was 43 ± 17 years and 89% were female. Within the reported immune diseases, 69% were well-defined immune diseases (autoimmune, autoinflammation, and mixed pattern diseases). Among the well-defined immune diseases following the exposure to adjuvants, polygenic autoimmune diseases were significantly higher than autoinflammatory disorders (92.7% vs 5.8%, respectively, p < 0.001). Polygenic autoimmune diseases such as connective tissue diseases were significantly linked to the exposure to HBV vaccine (OR 3.15 [95%CI 1.08-9.23], p = 0.036). Polygenic autoinflammatory diseases were significantly associated with the exposure to influenza vaccination (OR 10.98 [95%CI 3.81-31.67], p < 0.0001).CONCLUSIONS: Immune conditions following vaccination are rare, and among these, polygenic autoimmune diseases represent the vast majority of the well-defined immune diseases reported under the umbrella ASIA syndrome. However, vaccines benefit outweighs their autoimmune side effects.",

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author = "Abdulla Watad and Bragazzi, {Nicola Luigi} and Dennis McGonagle and Mohammed Adawi and Charlie Bridgewood and Giovanni Damiani and Jaume Alijotas-Reig and Enrique Esteve-Valverde and Mariana Quaresma and Howard Amital and Yehuda Shoenfeld",

year = "2019",

month = jun,

doi = "10.1016/j.clim.2019.03.007",

language = "English",

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pages = "1--8",

journal = "Clinical Immunology",

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Watad, A, Bragazzi, NL, McGonagle, D, Adawi, M, Bridgewood, C, Damiani, G, Alijotas-Reig, J , Esteve-Valverde, E, Quaresma, M, Amital, H & Shoenfeld, Y 2019, 'Autoimmune/inflammatory syndrome induced by adjuvants (ASIA) demonstrates distinct autoimmune and autoinflammatory disease associations according to the adjuvant subtype: Insights from an analysis of 500 cases', Clinical Immunology, vol. 203, pp. 1-8. https://doi.org/10.1016/j.clim.2019.03.007

Autoimmune/inflammatory syndrome induced by adjuvants (ASIA) demonstrates distinct autoimmune and autoinflammatory disease associations according to the adjuvant subtype: Insights from an analysis of 500 cases. / Watad, Abdulla; Bragazzi, Nicola Luigi; McGonagle, Dennis et al.
In: Clinical Immunology, Vol. 203, 06.2019, p. 1-8.

Research output: Contribution to journal › Article › Research › peer-review

TY - JOUR

T1 - Autoimmune/inflammatory syndrome induced by adjuvants (ASIA) demonstrates distinct autoimmune and autoinflammatory disease associations according to the adjuvant subtype

T2 - Insights from an analysis of 500 cases

AU - Watad, Abdulla

AU - Bragazzi, Nicola Luigi

AU - McGonagle, Dennis

AU - Adawi, Mohammed

AU - Bridgewood, Charlie

AU - Damiani, Giovanni

AU - Alijotas-Reig, Jaume

AU - Esteve-Valverde, Enrique

AU - Quaresma, Mariana

AU - Amital, Howard

AU - Shoenfeld, Yehuda

PY - 2019/6

Y1 - 2019/6

N2 - BACKGROUND: We investigated the pattern of reported immune diseases in the international ASIA syndrome registry.METHODS: Data from 500 subjects exposed to adjuvants from the ASIA syndrome international registry were analysed.RESULTS: The patient mean age was 43 ± 17 years and 89% were female. Within the reported immune diseases, 69% were well-defined immune diseases (autoimmune, autoinflammation, and mixed pattern diseases). Among the well-defined immune diseases following the exposure to adjuvants, polygenic autoimmune diseases were significantly higher than autoinflammatory disorders (92.7% vs 5.8%, respectively, p < 0.001). Polygenic autoimmune diseases such as connective tissue diseases were significantly linked to the exposure to HBV vaccine (OR 3.15 [95%CI 1.08-9.23], p = 0.036). Polygenic autoinflammatory diseases were significantly associated with the exposure to influenza vaccination (OR 10.98 [95%CI 3.81-31.67], p < 0.0001).CONCLUSIONS: Immune conditions following vaccination are rare, and among these, polygenic autoimmune diseases represent the vast majority of the well-defined immune diseases reported under the umbrella ASIA syndrome. However, vaccines benefit outweighs their autoimmune side effects.

AB - BACKGROUND: We investigated the pattern of reported immune diseases in the international ASIA syndrome registry.METHODS: Data from 500 subjects exposed to adjuvants from the ASIA syndrome international registry were analysed.RESULTS: The patient mean age was 43 ± 17 years and 89% were female. Within the reported immune diseases, 69% were well-defined immune diseases (autoimmune, autoinflammation, and mixed pattern diseases). Among the well-defined immune diseases following the exposure to adjuvants, polygenic autoimmune diseases were significantly higher than autoinflammatory disorders (92.7% vs 5.8%, respectively, p < 0.001). Polygenic autoimmune diseases such as connective tissue diseases were significantly linked to the exposure to HBV vaccine (OR 3.15 [95%CI 1.08-9.23], p = 0.036). Polygenic autoinflammatory diseases were significantly associated with the exposure to influenza vaccination (OR 10.98 [95%CI 3.81-31.67], p < 0.0001).CONCLUSIONS: Immune conditions following vaccination are rare, and among these, polygenic autoimmune diseases represent the vast majority of the well-defined immune diseases reported under the umbrella ASIA syndrome. However, vaccines benefit outweighs their autoimmune side effects.

KW - Adjuvants, Immunologic

KW - Adolescent

KW - Adult

KW - Aged

KW - Aged, 80 and over

KW - Autoimmune Diseases/epidemiology

KW - Child

KW - Child, Preschool

KW - Connective Tissue Diseases/epidemiology

KW - Female

KW - Giant Cell Arteritis/epidemiology

KW - Hepatitis B Vaccines/immunology

KW - Humans

KW - Infant

KW - Infant, Newborn

KW - Inflammation/epidemiology

KW - Influenza Vaccines/immunology

KW - Israel/epidemiology

KW - Male

KW - Middle Aged

KW - Syndrome

KW - Vaccination/statistics & numerical data

KW - Young Adult

U2 - 10.1016/j.clim.2019.03.007

DO - 10.1016/j.clim.2019.03.007

M3 - Article

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SN - 1521-6616

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JO - Clinical Immunology

JF - Clinical Immunology

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