Autoimmune/inflammatory syndrome induced by adjuvants (ASIA) demonstrates distinct autoimmune and autoinflammatory disease associations according to the adjuvant subtype: Insights from an analysis of 500 cases

Abdulla Watad, Nicola Luigi Bragazzi, Dennis McGonagle, Mohammed Adawi, Charlie Bridgewood, Giovanni Damiani, Jaume Alijotas-Reig, Enrique Esteve-Valverde, Mariana Quaresma, Howard Amital, Yehuda Shoenfeld

Research output: Contribution to journalArticleResearch

16 Citations (Scopus)

Abstract

© 2019 Elsevier Inc. Background: We investigated the pattern of reported immune diseases in the international ASIA syndrome registry. Methods: Data from 500 subjects exposed to adjuvants from the ASIA syndrome international registry were analysed. Results: The patient mean age was 43 ± 17 years and 89% were female. Within the reported immune diseases, 69% were well-defined immune diseases (autoimmune, autoinflammation, and mixed pattern diseases). Among the well-defined immune diseases following the exposure to adjuvants, polygenic autoimmune diseases were significantly higher than autoinflammatory disorders (92.7% vs 5.8%, respectively, p < 0.001). Polygenic autoimmune diseases such as connective tissue diseases were significantly linked to the exposure to HBV vaccine (OR 3.15 [95%CI 1.08–9.23], p = 0.036). Polygenic autoinflammatory diseases were significantly associated with the exposure to influenza vaccination (OR 10.98 [95%CI 3.81–31.67], p < 0.0001). Conclusions: Immune conditions following vaccination are rare, and among these, polygenic autoimmune diseases represent the vast majority of the well-defined immune diseases reported under the umbrella ASIA syndrome. However, vaccines benefit outweighs their autoimmune side effects.
Original languageEnglish
Pages (from-to)1-8
JournalClinical Immunology
Volume203
DOIs
Publication statusPublished - 1 Jun 2019

Keywords

  • ASIA syndrome
  • Foreign material
  • International syndrome registry
  • Silicone breast implants
  • Vaccines

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