Autoimmune neutropenia and thrombocytopenia associated with development of antibodies to human immunodeficiency virus

E. Ribera, I. Ocaña, B. Almirante, J. Gómez, P. Monreal, J. M. Martinez Vázquez

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18 Citations (Scopus)

Abstract

We report on two patients with acute human immunodeficiency virus (HIV) infection, who developed an infectious mononucleosis-like clinical episode with thrombocytopenia and granulocytopenia. In both cases we detected the presence of IgG antigranulocyte antibodies and in one case the presence of IgG, IgM and IgA antiplatelet antibodies. The mechanisms of these cytopenias are discussed. The association between such autoimmune cytopenias and acute HIV infection has not been previously reported. We suggest testing for HIV seroconversion in patients with a seronegative infectious mononucleosis-like syndrome belonging to groups with a high risk for HIV infection. © 1989 The British Society for the Study of Infection.
Original languageEnglish
Pages (from-to)167-170
JournalJournal of Infection
Volume18
Issue number2
DOIs
Publication statusPublished - 1 Jan 1989

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