Autoimmune gestational diabetes mellitus: A distinct clinical entity?

Dídac Mauricio, Alberto De Leiva

Research output: Contribution to journalReview articleResearchpeer-review

17 Citations (Scopus)

Abstract

This review gives an update of the present knowledge on what is defined here as autoimmune gestational diabetes mellitus (GDM). Autoimmune phenomena associated with type 1 diabetes mellitus (DM) can be detected in a subgroup of women with GDM. Islet autoantibodies are present in sera from women with GDM with variable frequency. Distinct phenotypic and genotypic features may be recognised in this subset of women with GDM, which are representative of a distinct clinical entity. Furthermore, these women are at increased risk of developing type 1 DM after pregnancy. However, the eventual progression of the autoimmune destruction of beta-cells in these subjects may follow different time-course patterns thus leading to variable forms of presentation of autoimmune DM. As a high-risk group for type 1 diabetes, women with previous autoimmune GDM may be candidates for potential immune intervention strategies. Copyright © 2001 John Wiley & Sons, Ltd.
Original languageEnglish
Pages (from-to)422-428
JournalDiabetes/Metabolism Research and Reviews
Volume17
Issue number6
DOIs
Publication statusPublished - 1 Dec 2001

Keywords

  • Autoimmunity
  • Genetics
  • Gestational diabetes mellitus
  • Type 1 diabetes mellitus

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