Autograft soaking in vancomycin reduces the risk of infection after anterior cruciate ligament reconstruction

Research output: Contribution to journalArticleResearchpeer-review

49 Citations (Scopus)

Abstract

© 2014, European Society of Sports Traumatology, Knee Surgery, Arthroscopy (ESSKA). Purpose: To determine whether the bathing of an anterior cruciate ligament (ACL) autograft in vancomycin reduces the rate of infection following an ACL reconstruction. Methods: Retrospective analysis of all ACL reconstructions over an 8-year period in two University Hospitals. In the initial 4-year period, all patients were operated on under classical antibiotic intravenous prophylaxis (group 1). Over the last 4-year period, this prophylaxis was supplemented with presoaking of the autograft (group 2). Presoaking was performed with sterile gauze previously saturated with a vancomycin solution (5 mg/ml). Results: There were 810 and 734 patients in group 1 and 2, respectively. Fifteen cases of knee joint infections were identified in the series (0.97 %). All of these infections occurred in group 1, representing a rate of infection of 1.85 % in comparison with 0 % in group 2 (p < 0.001). Conclusions: Autograft presoaking with vancomycin in combination with classical intravenous antibiotic prophylaxis reduced the rate of knee joint infection following an ACLR in comparison with antibiotic prophylaxis alone. This technique could be of relevance in daily clinical practice to prevent infection after ACLR. Level of evidence: Case control study, retrospective comparative study, Level III.
Original languageEnglish
Pages (from-to)2724-2728
JournalKnee Surgery, Sports Traumatology, Arthroscopy
Volume24
Issue number9
DOIs
Publication statusPublished - 1 Sep 2016

Keywords

  • Anterior cruciate ligament
  • Antibiotic prophylaxis
  • Biofilm
  • Knee infection
  • Vancomycin

Fingerprint Dive into the research topics of 'Autograft soaking in vancomycin reduces the risk of infection after anterior cruciate ligament reconstruction'. Together they form a unique fingerprint.

Cite this