Autoantibodies against a novel DNA-binding protein: DNA-protein interaction as a requisite for expression of antigenic reactivity

Candido Juarez, Jordi Lluis Vila, Manuela Agusti, Carmen Gelpi, Maria Jose Amengual, Sylvia Cardona, Jose Luis Rodriguez-Sanchez

    Research output: Contribution to journalArticleResearchpeer-review

    4 Citations (Scopus)

    Abstract

    A novel DNA-binding protein complex, the HB complex, has been characterized by means of autoantibodies. Three proteins of 9000, 7500, and 7000 Da constitute the HB complex. The 9000- and 7500-Da proteins are phosphorylated. Autoantibodies recognize the 7000-Da protein when it is bound to DNA. No reactivity against any protein was observed when the complex was dissociated from DNA. The three proteins are acidic (pI 5-6.2), and the complex was able to bind to synthetic double-stranded DNAs of different composition. © 1994 Academic Press, Inc.
    Original languageEnglish
    Pages (from-to)248-254
    JournalClinical Immunology and Immunopathology
    Volume72
    Issue number2
    DOIs
    Publication statusPublished - 1 Jan 1994

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