Atherogenic properties of LDL particles after switching from Truvada or Kivexa plus lopinavir/r to lamivudine plus lopinavir/r: OLE-MET substudy

Maria Saumoy, Juan M. Tiraboschi, Jordi Ordoñez-Llanos, Esteban Ribera, Pere Domingo, Josep Mallolas, Jordi Curto, Josep M. Gatell, Daniel Podzamczer

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Abstract

© 2017 Informa UK Limited, trading as Taylor & Francis Group. Background: The objective of this study was to determine the impact of tenofovir or abacavir discontinuation on low-density lipoprotein (LDL) phenotype and lipoprotein-associated phospholipase A2 (Lp-PLA2) activity in HIV-infected patients treated with lopinavir/ritonavir plus 2 nucleos(t)ide reverse transcriptase inhibitors (NRTI). Methods: Multicenter, open-label study. Patients were randomized to continue with lopinavir/ritonavir plus 2 NRTI (triple therapy) or to switch to lopinavir/ritonavir plus lamivudine (dual therapy). LDL phenotype (by gradient gel electrophoresis) and Lp-PLA2 (by 2-thio-PAF) were determined at baseline and week 48. Results: Forty-four patients included (triple therapy n = 19, dual therapy n = 25): men 63.6%, age 41.5 years (25–61), Framingham score 4.9% (0.2–22). Tenofovir was part of the regimen in 28 (63.6%) patients. Dual therapy patients were younger (p = 0.013) and had lower baseline apolipoprotein A1 (p = 0.029). At week 48, there were no changes in standard lipid measurements, except ApoA1/Apo B, which increased in dual therapy (p = 0.038) with no differences between arms. At week 48, no change in LDL phenotype was found in either arm. No changes in total Lp-PLA2 activity or the relative distribution of LDL and HDL particles were found at week 48 in either arm. Conclusions: Discontinuing the third nucleos(t)ide, mainly tenofovir and abacavir, in a lopinavir/ritonavir-containing regimen was not associated with a deleterious effect on LDL phenotype nor in Lp-PLA2 activity.
Original languageEnglish
Pages (from-to)49-53
JournalHIV Clinical Trials
Volume18
Issue number2
DOIs
Publication statusPublished - 4 Mar 2017

Keywords

  • Abacavir
  • LDL particles
  • Lipid profile
  • Lipoprotein-associated phospholipase A2
  • Lopinavir/ritonavir
  • Switch strategy
  • Tenofovir

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    Saumoy, M., Tiraboschi, J. M., Ordoñez-Llanos, J., Ribera, E., Domingo, P., Mallolas, J., Curto, J., Gatell, J. M., & Podzamczer, D. (2017). Atherogenic properties of LDL particles after switching from Truvada or Kivexa plus lopinavir/r to lamivudine plus lopinavir/r: OLE-MET substudy. HIV Clinical Trials, 18(2), 49-53. https://doi.org/10.1080/15284336.2016.1275425