Atherogenic dyslipidemia in patients with type 1 diabetes mellitus

Juan J. Chillarón, María P. Sales, Juana A. Flores Le-Roux, Ignasi Castells, David Benaiges, Enric Sagarra, Juan Pedro-Botet

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4 Citations (Scopus)

Abstract

Background and objective To assess the prevalence of lipid abnormalities, with special emphasis on atherogenic dyslipidemia and its relationship with chronic complications in patients with type 1 diabetes mellitus (T1DM). Patients and method Cross-sectional study including all patients aged 18 and over, diagnosed of T1DM attending the outpatient clinic at Hospital del Mar and Hospital de Granollers, in Barcelona, during 2008. Results Of the 291 enrolled patients, 17.2 and 7.9% had high density lipoproteins (HDL) cholesterol < 40 mg/dL (men) or < 50 mg/dL (women) and triglycerides > 150 mg/dL, respectively. Hypoalphalipoproteinemic patients had a higher prevalence of peripheral neuropathy (28 vs. 7.1%, P <.001), macroalbuminuria (14 vs. 2.5%, P <.001) and higher concentrations of triglycerides (107.5 [55.8] vs. 82.7 [36] mg/dL, P <.0001) compared with those with normal/high HDL cholesterol levels. Hypertriglyceridemia was associated with increasing age (43.6 [11.2] vs. 37.6 [11.8] yr, P <.02), higher prevalence of hypertension (47.8 vs. 22.8%, P <.008), metabolic syndrome (82.6 vs. 22%, P <.001) and microangiopathic complications, lower insulin sensitivity (6.75 [2.1] vs. 8.54 [2.6] mg/Kg -1/min-1, P <.004) compared with the normotriglyceridemic group. Conclusion One in 5 patients with T1DM has hypoalphalipoproteinemia or hypertriglyceridemia and these conditions are associated with 3 fold-increase microangiopathy. Thus, in these patients glycemic and blood pressure but also lipid profile control must be optimum. © 2013 Elsevier España, S.L. All rights reserved.
Original languageEnglish
Pages (from-to)465-470
JournalMedicina Clinica
Volume141
Issue number11
DOIs
Publication statusPublished - 7 Dec 2013

Keywords

  • Atherogenic dyslipidemia
  • Lipid abnormalities
  • Macrovascular complications
  • Metabolic control
  • Microvascular complications
  • Type 1 diabetes

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