A stereoselective synthesis of l-carbidopa in seven steps and 50% overall yield from commercial compounds is described. The key step involves a highly enantioselective α-amination reaction of an acyclic β-ketoester with di-tert-butyl azodicarboxylate induced by europium and (R,R)-diphenyl-pybox. © 2013 American Chemical Society.
|Publication status||Published - 5 Apr 2013|
Pericas, L., Shafir, A., & Vallribera, A. (2013). Asymmetric Synthesis of L-carbidopa based on a highly enantioselective α-amination. Organic Letters, 15(7), 1448-1451. https://doi.org/10.1021/ol400136y