Asymmetric Synthesis of L-carbidopa based on a highly enantioselective α-amination

Lex Pericas; Alexandr Shafir; Adelina Vallribera

doi:10.1021/ol400136y

Asymmetric Synthesis of L-carbidopa based on a highly enantioselective α-amination

Lex Pericas, Alexandr Shafir, Adelina Vallribera

Department of Chemistry

Research output: Contribution to journal › Article › Research › peer-review

26 Citations (Scopus)

Abstract

A stereoselective synthesis of l-carbidopa in seven steps and 50% overall yield from commercial compounds is described. The key step involves a highly enantioselective α-amination reaction of an acyclic β-ketoester with di-tert-butyl azodicarboxylate induced by europium and (R,R)-diphenyl-pybox. © 2013 American Chemical Society.

Original language	English
Pages (from-to)	1448-1451
Journal	Organic Letters
Volume	15
Issue number	7
DOIs	https://doi.org/10.1021/ol400136y
Publication status	Published - 5 Apr 2013

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abstract = "A stereoselective synthesis of l-carbidopa in seven steps and 50% overall yield from commercial compounds is described. The key step involves a highly enantioselective α-amination reaction of an acyclic β-ketoester with di-tert-butyl azodicarboxylate induced by europium and (R,R)-diphenyl-pybox. {\textcopyright} 2013 American Chemical Society.",

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AB - A stereoselective synthesis of l-carbidopa in seven steps and 50% overall yield from commercial compounds is described. The key step involves a highly enantioselective α-amination reaction of an acyclic β-ketoester with di-tert-butyl azodicarboxylate induced by europium and (R,R)-diphenyl-pybox. © 2013 American Chemical Society.

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Asymmetric Synthesis of L-carbidopa based on a highly enantioselective α-amination

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