Asymmetric Synthesis of L-carbidopa based on a highly enantioselective α-amination

Lex Pericas, Alexandr Shafir, Adelina Vallribera

Research output: Contribution to journalArticleResearchpeer-review

23 Citations (Scopus)

Abstract

A stereoselective synthesis of l-carbidopa in seven steps and 50% overall yield from commercial compounds is described. The key step involves a highly enantioselective α-amination reaction of an acyclic β-ketoester with di-tert-butyl azodicarboxylate induced by europium and (R,R)-diphenyl-pybox. © 2013 American Chemical Society.
Original languageEnglish
Pages (from-to)1448-1451
JournalOrganic Letters
Volume15
Issue number7
DOIs
Publication statusPublished - 5 Apr 2013

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