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Abstract
In this review, recent advances over the past decade in the preparation of fluorinated stereogenic quaternary centers on β-keto esters compounds are analyzed. Since the incorporation of fluorine and fluorinated groups is of special interest in pharmaceutical chemistry, a range of metal-catalyzed and organocatalyzed methods have been developed. Herein, we review the enantioselective fluorination, trifluoromethylation and trifluoromethylthiolation of 3-oxo esters. The scope, the induction of enantioselectivity and mechanistic investigations are presented.
Original language | English |
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Article number | 3264 |
Journal | Molecules |
Volume | 25 |
Issue number | 14 |
DOIs | |
Publication status | Published - 17 Jul 2020 |
Keywords
- Fluorination
- Trifluoromethylation
- Trifluoromethylthiolation
- β-keto esters
- Asymmetric
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- 1 Finished
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QUIMICA ORGANOFLUORADA: METODOS EMERGENTES DE FLUORACION Y TEJIDOS DE ALGODON PARA USOS MEDICOS
Vallribera Masso, A. (Principal Investigator), Pleixats Rovira, R. (Principal Investigator 2), Fernandez Freixes, G. (Collaborator), Granados Toda, A. (Collaborator), Li , H. (Collaborator), Liu, M. (Collaborator) & Gimbert Suriñach, C. (Collaborator)
Spanish Ministry of Economy and Competitiveness (MINECO)
1/01/19 → 30/09/22
Project: Research Projects and Other Grants