TY - JOUR
T1 - Asymmetric hybrid silica nanomotors for capture and cargo transport: Towards a novel motion-based DNA sensor
AU - Simmchen, Juliane
AU - Baeza, Alejandro
AU - Ruiz, Daniel
AU - Esplandiu, Maria José
AU - Vallet-Regí, Maria
PY - 2012/7/9
Y1 - 2012/7/9
N2 - An innovative self-propelled nanodevice able to perform motion, cargo transport, and target recognition is presented. The system is based on a mesoporous motor particle, which is asymmetrically functionalized by the attachment of single-stranded DNA onto one of its faces, while catalase is immobilized on the other face. This enzyme allows catalytic decomposition of hydrogen peroxide to oxygen and water, giving rise to the driving force for the motion of the whole system. Moreover the motor particles are able to capture and transport cargo particles functionalized with a noncomplementary single-stranded DNA molecule, only if a specific oligonucleotide sequence is present in the media. Functionalization with characteristic oligonucleotide sequences in the system implies a potential for further developments for lab-on-chip devices with applications in biomedical applications. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
AB - An innovative self-propelled nanodevice able to perform motion, cargo transport, and target recognition is presented. The system is based on a mesoporous motor particle, which is asymmetrically functionalized by the attachment of single-stranded DNA onto one of its faces, while catalase is immobilized on the other face. This enzyme allows catalytic decomposition of hydrogen peroxide to oxygen and water, giving rise to the driving force for the motion of the whole system. Moreover the motor particles are able to capture and transport cargo particles functionalized with a noncomplementary single-stranded DNA molecule, only if a specific oligonucleotide sequence is present in the media. Functionalization with characteristic oligonucleotide sequences in the system implies a potential for further developments for lab-on-chip devices with applications in biomedical applications. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
KW - catalytic nanomotors
KW - fluorescence
KW - hydrogen peroxide
KW - self-assembly
KW - sensors
U2 - 10.1002/smll.201101593
DO - 10.1002/smll.201101593
M3 - Article
VL - 8
SP - 2053
EP - 2059
JO - Small
JF - Small
SN - 1613-6810
IS - 13
ER -